EMDB/PDB/SASBDBから引用されている文献のデータベース

キーワード
構造解析手法	All X線回折 NMR 電子顕微鏡小角散乱中性子線回折線維回折粉末回折赤外分光 EPR FRET 理論モデルハイブリッド
著者・登録者
ジャーナル
IF	>30 >20 >10 >5 all

タイトル	Zinc-Metalloproteinase Inhibitors: Evaluation of the Complex Role Played by the Zinc-Binding Group on Potency and Selectivity.
ジャーナル・号・ページ	J. Med. Chem., Vol. 60, Page 403-414, Year 2017
掲載日	2015年7月28日 (構造データの登録日)
著者	Rouanet-Mehouas, C. / Czarny, B. / Beau, F. / Cassar-Lajeunesse, E. / Stura, E.A. / Dive, V. / Devel, L.
リンク	J. Med. Chem. / PubMed:27996256
手法	X線回折
解像度	1.2 - 1.314 Å
構造データ	PDB-5cxa: Crystal structure of the catalytic domain of Human MMP12 in complex with a carboxylate inhibitor related to RXP470 手法: X-RAY DIFFRACTION / 解像度: 1.3 Å PDB-5czm: Crystal structure of a mutated catalytic domain of Human MMP12 in complex with RXP470 手法: X-RAY DIFFRACTION / 解像度: 1.303 Å PDB-5d2b: Crystal structure of a mutated catalytic domain of Human MMP12 in complex with an hydroxamate analogue of RXP470 手法: X-RAY DIFFRACTION / 解像度: 1.2 Å PDB-5d3c: Crystal structure of a double mutant catalytic domain of Human MMP12 in complex with an hydroxamate analogue of RXP470 手法: X-RAY DIFFRACTION / 解像度: 1.314 Å
化合物	ChemComp-ZN: Unknown entry ChemComp-CA: Unknown entry / カルシウムジカチオン ChemComp-55L: (R)-4-(((S)-1-(((S)-1-amino-4-carboxy-1-oxobutan-2-yl)amino)-4-carboxy-1-oxobutan-2-yl)amino)-3-((3-(3'-chloro-[1,1'-biphenyl]-4-yl)isoxazol-5-yl)methyl)-4-oxobutanoate ChemComp-HOH: WATER ChemComp-R47: N-[(2S)-3-[(S)-(4-bromophenyl)(hydroxy)phosphoryl]-2-{[3-(3'-chlorobiphenyl-4-yl)-1,2-oxazol-5-yl]methyl}propanoyl]-L-alpha-glutamyl-L-alpha-glutamine ChemComp-56O: N-[(2R)-2-{[3-(3'-chlorobiphenyl-4-yl)-1,2-oxazol-5-yl]methyl}-4-(hydroxyamino)-4-oxobutanoyl]-L-alpha-glutamyl-L-alpha-glutamine
由来	homo sapiens (ヒト)
キーワード	HYDROLASE / metzincin / RXP470 / carboxylate based inhibitor / carboxylate peptidic inhibitor / Matrix / Metallo Elastase / MMP12 / human / Macrophage / Matrix Metallo Elastase / Hydroxamate based inhibitor / Macrophage MetalloElastase / hydroxamate