タイトル | Ancient Origin of cGAS-STING Reveals Mechanism of Universal 2',3' cGAMP Signaling. |
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ジャーナル・号・ページ | Mol. Cell, Vol. 59, Page 891-903, Year 2015 |
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掲載日 | 2015年7月8日 (構造データの登録日) |
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著者 | Kranzusch, P.J. / Wilson, S.C. / Lee, A.S. / Berger, J.M. / Doudna, J.A. / Vance, R.E. |
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リンク | Mol. Cell / PubMed:26300263 |
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手法 | X線回折 |
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解像度 | 1.836 - 2.95 Å |
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構造データ | PDB-5cfl: Crystal structure of anemone STING (Nematostella vectensis) in complex with 3', 3' c-di-GMP, c[G(3', 5')pG(3', 5')p] 手法: X-RAY DIFFRACTION / 解像度: 1.836 Å PDB-5cfm: Crystal structure of anemone STING (Nematostella vectensis) in complex with 3', 3' cGAMP, c[G(3', 5')pA(3', 5')p] 手法: X-RAY DIFFRACTION / 解像度: 1.994 Å PDB-5cfn: Crystal structure of anemone STING (Nematostella vectensis) in complex with 3',3' c-di-AMP, c[A(3',5')pA(3',5')p] 手法: X-RAY DIFFRACTION / 解像度: 2.95 Å PDB-5cfo: Crystal structure of anemone STING (Nematostella vectensis) in apo 'rotated' open conformation 手法: X-RAY DIFFRACTION / 解像度: 2.102 Å PDB-5cfp: Crystal structure of anemone STING (Nematostella vectensis) 'humanized' F276K in complex with 3', 3' c-di-GMP, c[G(3', 5')pG(3', 5')p]' 手法: X-RAY DIFFRACTION / 解像度: 2.066 Å PDB-5cfq: Crystal structure of anemone STING (Nematostella vectensis) in complex with 2',3' cGAMP, c[G(2',5')pA(3',5')p] 手法: X-RAY DIFFRACTION / 解像度: 2.099 Å PDB-5cfr: Crystal structure of anemone STING (Nematostella vectensis) in apo 'unrotated' closed conformation 手法: X-RAY DIFFRACTION / 解像度: 2.85 Å |
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化合物 | ChemComp-C2E: 9,9'-[(2R,3R,3aS,5S,7aR,9R,10R,10aS,12S,14aR)-3,5,10,12-tetrahydroxy-5,12-dioxidooctahydro-2H,7H-difuro[3,2-d:3',2'-j][1,3,7,9,2,8]tetraoxadiphosphacyclododecine-2,9-diyl]bis(2-amino-1,9-dihydro-6H-purin-6-one) / c-di-GMP
ChemComp-4BW: 2-amino-9-[(2R,3R,3aS,5R,7aR,9R,10R,10aS,12R,14aR)-9-(6-amino-9H-purin-9-yl)-3,5,10,12-tetrahydroxy-5,12-dioxidooctahydro-2H,7H-difuro[3,2-d:3',2'-j][1,3,7,9,2,8]tetraoxadiphosphacyclododecin-2-yl]-1,9-dihydro-6H-purin-6-one / cGAMP
ChemComp-2BA: (2R,3R,3aS,5R,7aR,9R,10R,10aS,12R,14aR)-2,9-bis(6-amino-9H-purin-9-yl)octahydro-2H,7H-difuro[3,2-d:3',2'-j][1,3,7,9,2,8 / c-di-AMP
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由来 | - nematostella vectensis (イソギンチャク)
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キーワード | IMMUNE SYSTEM / STING / Cyclic-dinucleotide Binding Domain |
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