EMDB/PDB/SASBDBから引用されている文献のデータベース

キーワード
構造解析手法	All X線回折 NMR 電子顕微鏡小角散乱中性子線回折線維回折粉末回折赤外分光 EPR FRET 理論モデルハイブリッド
著者・登録者
ジャーナル
IF	>30 >20 >10 >5 all

タイトル	Fragment-Based Drug Discovery Targeting Inhibitor of Apoptosis Proteins: Discovery of a Non-Alanine Lead Series with Dual Activity Against cIAP1 and XIAP.
ジャーナル・号・ページ	J. Med. Chem., Vol. 58, Page 6574-6588, Year 2015
掲載日	2015年6月12日 (構造データの登録日)
著者	Chessari, G. / Buck, I.M. / Day, J.E. / Day, P.J. / Iqbal, A. / Johnson, C.N. / Lewis, E.J. / Martins, V. / Miller, D. / Reader, M. ...Chessari, G. / Buck, I.M. / Day, J.E. / Day, P.J. / Iqbal, A. / Johnson, C.N. / Lewis, E.J. / Martins, V. / Miller, D. / Reader, M. / Rees, D.C. / Rich, S.J. / Tamanini, E. / Vitorino, M. / Ward, G.A. / Williams, P.A. / Williams, G. / Wilsher, N.E. / Woolford, A.J.
リンク	J. Med. Chem. / PubMed:26218264
手法	X線回折
解像度	2.02 - 2.68 Å
構造データ	PDB-5c0k: Fragment-Based Drug Discovery Targeting Inhibitor of Apoptosis Proteins: Compound 3 手法: X-RAY DIFFRACTION / 解像度: 2.2 Å PDB-5c0l: Fragment-Based Drug Discovery Targeting Inhibitor of Apoptosis Proteins: Compound 2 手法: X-RAY DIFFRACTION / 解像度: 2.6 Å PDB-5c3h: Fragment-Based Drug Discovery Targeting Inhibitor of Apoptosis Proteins: Compound 1 手法: X-RAY DIFFRACTION / 解像度: 2.65 Å PDB-5c3k: Fragment-Based Drug Discovery Targeting Inhibitor of Apoptosis Proteins: Compound 4 手法: X-RAY DIFFRACTION / 解像度: 2.02 Å PDB-5c7a: Fragment-Based Drug Discovery Targeting Inhibitor of Apoptosis Proteins: Compound 7 手法: X-RAY DIFFRACTION / 解像度: 2.36 Å PDB-5c7b: Fragment-Based Drug Discovery Targeting Inhibitor of Apoptosis Proteins: Compound 5 手法: X-RAY DIFFRACTION / 解像度: 2.68 Å PDB-5c7c: Fragment-Based Drug Discovery Targeting Inhibitor of Apoptosis Proteins: Compound 18 手法: X-RAY DIFFRACTION / 解像度: 2.32 Å PDB-5c7d: Fragment-Based Drug Discovery Targeting Inhibitor of Apoptosis Proteins: Compound 17 手法: X-RAY DIFFRACTION / 解像度: 2.25 Å PDB-5c83: Fragment-Based Drug Discovery Targeting Inhibitor of Apoptosis Proteins: Compound 21 手法: X-RAY DIFFRACTION / 解像度: 2.33 Å PDB-5c84: Fragment-Based Drug Discovery Targeting Inhibitor of Apoptosis Proteins: Compound 20 手法: X-RAY DIFFRACTION / 解像度: 2.36 Å
化合物	ChemComp-ZN: Unknown entry ChemComp-EDO: 1,2-ETHANEDIOL / エチレングリコ-ル ChemComp-4WK: (2S)-1-{[(2S)-1-amino-3-methyl-1-oxobutan-2-yl]amino}-1-oxopropan-2-aminium ChemComp-HOH: WATER ChemComp-4WJ: 4-(4-bromo-1H-pyrazol-1-yl)piperidinium ChemComp-4XE: 4-[2-oxo-2-(piperidin-1-yl)ethyl]piperazin-1-ium ChemComp-4XF: (2S)-1-[(6-aminopyridin-2-yl)amino]-1-oxopropan-2-aminium ChemComp-4YE: (2R)-4-[2-(2,3-dihydro-1H-indol-1-yl)-2-oxoethyl]-2-methylpiperazin-1-ium ChemComp-4YD: (2R)-2-methyl-4-[2-oxo-2-(pyrrolidin-1-yl)ethyl]piperazin-1-ium ChemComp-4YC: (2R)-4-[2-(6-chloro-3,3-dimethyl-2,3-dihydro-1H-indol-1-yl)-2-oxoethyl]-2-methylpiperazin-1-ium ChemComp-4YF: (2R)-4-[2-(6-chloro-2,3-dihydro-1H-pyrrolo[3,2-c]pyridin-1-yl)-2-oxoethyl]-2-methylpiperazin-1-ium ChemComp-4YN: (2R,5R)-4-[2-(6-benzyl-3,3-dimethyl-2,3-dihydro-1H-pyrrolo[3,2-c]pyridin-1-yl)-2-oxoethyl]-5-(methoxymethyl)-2-methylpiperazin-1-ium ChemComp-4YL: (2R,5R)-4-[2-(6-chloro-3,3-dimethyl-2,3-dihydro-1H-pyrrolo[3,2-c]pyridin-1-yl)-2-oxoethyl]-5-(methoxymethyl)-2-methylpiperazin-1-ium
由来	homo sapiens (ヒト)
キーワード	APOPTOSIS / ligase