タイトル | Crystal structure and stability of gyrase-fluoroquinolone cleaved complexes from Mycobacterium tuberculosis. |
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ジャーナル・号・ページ | Proc. Natl. Acad. Sci. USA, Vol. 113, Page 1706-1713, Year 2016 |
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掲載日 | 2015年6月1日 (構造データの登録日) |
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著者 | Blower, T.R. / Williamson, B.H. / Kerns, R.J. / Berger, J.M. |
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リンク | Proc. Natl. Acad. Sci. USA / PubMed:26792525 |
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手法 | X線回折 |
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解像度 | 2.399 - 2.61 Å |
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構造データ | PDB-5bs8: Crystal structure of a topoisomerase II complex 手法: X-RAY DIFFRACTION / 解像度: 2.399 Å PDB-5bta: Crystal structure of a topoisomerase II complex 手法: X-RAY DIFFRACTION / 解像度: 2.55 Å PDB-5btc: Crystal structure of a topoisomerase II complex 手法: X-RAY DIFFRACTION / 解像度: 2.55 Å PDB-5btd: Crystal structure of a topoisomerase II complex 手法: X-RAY DIFFRACTION / 解像度: 2.497 Å PDB-5btf: Crystal structure of a topoisomerase II complex 手法: X-RAY DIFFRACTION / 解像度: 2.61 Å PDB-5btg: Crystal structure of a topoisomerase II complex 手法: X-RAY DIFFRACTION / 解像度: 2.5 Å PDB-5bti: Crystal structure of a topoisomerase II complex 手法: X-RAY DIFFRACTION / 解像度: 2.501 Å PDB-5btl: Crystal structure of a topoisomerase II complex 手法: X-RAY DIFFRACTION / 解像度: 2.5 Å PDB-5btn: Crystal structure of a topoisomerase II complex 手法: X-RAY DIFFRACTION / 解像度: 2.5 Å |
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化合物 | ChemComp-MFX: 1-cyclopropyl-6-fluoro-8-methoxy-7-[(4aS,7aS)-octahydro-6H-pyrrolo[3,4-b]pyridin-6-yl]-4-oxo-1,4-dihydroquinoline-3-carboxylic acid / モキシフロキサシン / 抗生剤*YM
ChemComp-CPF: 1-CYCLOPROPYL-6-FLUORO-4-OXO-7-PIPERAZIN-1-YL-1,4-DIHYDROQUINOLINE-3-CARBOXYLIC ACID / シプロフロキサシン / 抗生剤*YM
ChemComp-GFN: 1-cyclopropyl-6-fluoro-8-methoxy-7-[(3S)-3-methylpiperazin-1-yl]-4-oxo-1,4-dihydroquinoline-3-carboxylic acid / 抗生剤*YM
ChemComp-LFX: (3S)-9-fluoro-3-methyl-10-(4-methylpiperazin-1-yl)-7-oxo-2,3-dihydro-7H-[1,4]oxazino[2,3,4-ij]quinoline-6-carboxylic acid / レボフロキサシン / 薬剤, 抗生剤*YM
ChemComp-8MX: 1-cyclopropyl-6-fluoro-8-methyl-7-[(4aS,7aS)-octahydro-6H-pyrrolo[3,4-b]pyridin-6-yl]-4-oxo-1,4-dihydroquinoline-3-carboxylic acid
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由来 | - mycobacterium tuberculosis (strain atcc 25618 / h37rv) (結核菌)
- synthetic construct (人工物)
- mycobacterium tuberculosis (strain cdc 1551 / oshkosh) (結核菌)
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キーワード | Isomerase/DNA / protein-DNA complex / topoisomerase II / Isomerase-DNA complex |
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