EMDB/PDB/SASBDBから引用されている文献のデータベース

キーワード
構造解析手法	All X線回折 NMR 電子顕微鏡小角散乱中性子線回折線維回折粉末回折赤外分光 EPR FRET 理論モデルハイブリッド
著者・登録者
ジャーナル
IF	>30 >20 >10 >5 all

タイトル	Successful Generation of Structural Information for Fragment-Based Drug Discovery.
ジャーナル・号・ページ	Drug Discov Today, Vol. 20, Page 1104-, Year 2015
掲載日	2015年2月10日 (構造データの登録日)
著者	Oster, L. / Tapani, S. / Xue, Y. / Kack, H.
リンク	Drug Discov Today / PubMed:25931264
手法	X線回折
解像度	1.7 - 2.78 Å
構造データ	PDB-5ahx: Apo structure of soluble epoxide hydrolase 手法: X-RAY DIFFRACTION / 解像度: 2 Å PDB-5ai0: Ligand complex structure of soluble epoxide hydrolase 手法: X-RAY DIFFRACTION / 解像度: 1.75 Å PDB-5ai4: ligand complex structure of soluble epoxide hydrolase 手法: X-RAY DIFFRACTION / 解像度: 1.93 Å PDB-5ai5: ligand complex structure of soluble epoxide hydrolase 手法: X-RAY DIFFRACTION / 解像度: 2.28 Å PDB-5ai6: ligand complex structure of soluble epoxide hydrolase 手法: X-RAY DIFFRACTION / 解像度: 2.3 Å PDB-5ai8: ligand complex structure of soluble epoxide hydrolase 手法: X-RAY DIFFRACTION / 解像度: 1.85 Å PDB-5ai9: ligand complex structure of soluble epoxide hydrolase 手法: X-RAY DIFFRACTION / 解像度: 1.8 Å PDB-5aia: ligand complex structure of soluble epoxide hydrolase 手法: X-RAY DIFFRACTION / 解像度: 2.26 Å PDB-5aib: ligand complex structure of soluble epoxide hydrolase 手法: X-RAY DIFFRACTION / 解像度: 1.95 Å PDB-5aic: ligand complex structure of soluble epoxide hydrolase 手法: X-RAY DIFFRACTION / 解像度: 1.89 Å PDB-5ak3: ligand complex structure of soluble epoxide hydrolase 手法: X-RAY DIFFRACTION / 解像度: 2.28 Å PDB-5ak4: ligand complex structure of soluble epoxide hydrolase 手法: X-RAY DIFFRACTION / 解像度: 1.79 Å PDB-5ak5: ligand complex structure of soluble epoxide hydrolase 手法: X-RAY DIFFRACTION / 解像度: 2.22 Å PDB-5ak6: ligand complex structure of soluble epoxide hydrolase 手法: X-RAY DIFFRACTION / 解像度: 2.15 Å PDB-5ake: ligand complex structure of soluble epoxide hydrolase 手法: X-RAY DIFFRACTION / 解像度: 2.26 Å PDB-5akg: ligand complex structure of soluble epoxide hydrolase 手法: X-RAY DIFFRACTION / 解像度: 2.51 Å PDB-5akh: ligand complex structure of soluble epoxide hydrolase 手法: X-RAY DIFFRACTION / 解像度: 2.1 Å PDB-5aki: ligand complex structure of soluble epoxide hydrolase 手法: X-RAY DIFFRACTION / 解像度: 1.81 Å PDB-5akj: ligand complex structure of soluble epoxide hydrolase 手法: X-RAY DIFFRACTION / 解像度: 2.03 Å PDB-5akk: ligand complex structure of soluble epoxide hydrolase 手法: X-RAY DIFFRACTION / 解像度: 1.9 Å PDB-5akl: ligand complex structure of soluble epoxide hydrolase 手法: X-RAY DIFFRACTION / 解像度: 2 Å PDB-5akx: ligand complex structure of soluble epoxide hydrolase 手法: X-RAY DIFFRACTION / 解像度: 2.09 Å PDB-5aky: ligand complex structure of soluble epoxide hydrolase 手法: X-RAY DIFFRACTION / 解像度: 2.18 Å PDB-5akz: ligand complex structure of soluble epoxide hydrolase 手法: X-RAY DIFFRACTION / 解像度: 2.18 Å PDB-5ald: ligand complex structure of soluble epoxide hydrolase 手法: X-RAY DIFFRACTION / 解像度: 2.26 Å PDB-5ale: ligand complex structure of soluble epoxide hydrolase 手法: X-RAY DIFFRACTION / 解像度: 1.95 Å PDB-5alf: ligand complex structure of soluble epoxide hydrolase 手法: X-RAY DIFFRACTION / 解像度: 2.32 Å PDB-5alg: ligand complex structure of soluble epoxide hydrolase 手法: X-RAY DIFFRACTION / 解像度: 2.4 Å PDB-5alh: ligand complex structure of soluble epoxide hydrolase 手法: X-RAY DIFFRACTION / 解像度: 1.9 Å PDB-5ali: ligand complex structure of soluble epoxide hydrolase 手法: X-RAY DIFFRACTION / 解像度: 1.85 Å PDB-5alj: ligand complex structure of soluble epoxide hydrolase 手法: X-RAY DIFFRACTION / 解像度: 2.1 Å PDB-5alk: ligand complex structure of soluble epoxide hydrolase 手法: X-RAY DIFFRACTION / 解像度: 2.33 Å PDB-5all: ligand complex structure of soluble epoxide hydrolase 手法: X-RAY DIFFRACTION / 解像度: 2.2 Å PDB-5alm: ligand complex structure of soluble epoxide hydrolase 手法: X-RAY DIFFRACTION / 解像度: 2 Å PDB-5aln: ligand complex structure of soluble epoxide hydrolase 手法: X-RAY DIFFRACTION / 解像度: 2 Å PDB-5alo: ligand complex structure of soluble epoxide hydrolase 手法: X-RAY DIFFRACTION / 解像度: 2 Å PDB-5alp: ligand complex structure of soluble epoxide hydrolase 手法: X-RAY DIFFRACTION / 解像度: 2.06 Å PDB-5alq: ligand complex structure of soluble epoxide hydrolase 手法: X-RAY DIFFRACTION / 解像度: 2.78 Å PDB-5alr: ligand complex structure of soluble epoxide hydrolase 手法: X-RAY DIFFRACTION / 解像度: 2.6 Å PDB-5als: ligand complex structure of soluble epoxide hydrolase 手法: X-RAY DIFFRACTION / 解像度: 2.57 Å PDB-5alt: ligand complex structure of soluble epoxide hydrolase 手法: X-RAY DIFFRACTION / 解像度: 2.15 Å PDB-5alu: ligand complex structure of soluble epoxide hydrolase 手法: X-RAY DIFFRACTION / 解像度: 1.87 Å PDB-5alv: ligand complex structure of soluble epoxide hydrolase 手法: X-RAY DIFFRACTION / 解像度: 1.8 Å PDB-5alw: ligand complex structure of soluble epoxide hydrolase 手法: X-RAY DIFFRACTION / 解像度: 2.2 Å PDB-5alx: ligand complex structure of soluble epoxide hydrolase 手法: X-RAY DIFFRACTION / 解像度: 2.23 Å PDB-5aly: ligand complex structure of soluble epoxide hydrolase 手法: X-RAY DIFFRACTION / 解像度: 1.9 Å PDB-5alz: ligand complex structure of soluble epoxide hydrolase 手法: X-RAY DIFFRACTION / 解像度: 2.3 Å PDB-5am0: ligand complex structure of soluble epoxide hydrolase 手法: X-RAY DIFFRACTION / 解像度: 1.88 Å PDB-5am1: ligand complex structure of soluble epoxide hydrolase 手法: X-RAY DIFFRACTION / 解像度: 2.15 Å PDB-5am2: ligand complex structure of soluble epoxide hydrolase 手法: X-RAY DIFFRACTION / 解像度: 1.7 Å PDB-5am3: ligand complex structure of soluble epoxide hydrolase 手法: X-RAY DIFFRACTION / 解像度: 2.2 Å PDB-5am4: ligand complex structure of soluble epoxide hydrolase 手法: X-RAY DIFFRACTION / 解像度: 1.87 Å PDB-5am5: ligand complex structure of soluble epoxide hydrolase 手法: X-RAY DIFFRACTION / 解像度: 2.26 Å
化合物	ChemComp-SO4: SULFATE ION / 硫酸ジアニオン ChemComp-GOL: GLYCEROL / グリセロ-ル ChemComp-HOH: WATER ChemComp-PEG: DI(HYDROXYETHYL)ETHER / ジエチレングリコ-ル ChemComp-DMS: DIMETHYL SULFOXIDE / 2-チアプロパン2-オキシド / DMSO, 沈殿剤YM ChemComp-JF6: 4-PHENYL-1,2,5-OXADIAZOL-3-AMINE / 4-フェニルフラザン-3-アミン ChemComp-4VY: 2-[(5-BROMO-2-PYRIDYL)-METHYL-AMINO]ETHANOL ChemComp-BSU: 1,3-DIPHENYLUREA / 1,3-ジフェニル尿素 / ホルモンYM ChemComp-4XH: 5-BROMOQUINOLINE / 5-ブロモキノリン ChemComp-K2T: 6-methyl-1,3-benzothiazol-2-amine / 6-メチルベンゾチアゾ-ル-2-アミン ChemComp-K78: 2-bromo-4-tert-butyl-6-{[(3-phenylpropyl)amino]methyl}phenol ChemComp-KWB: 5-cyclohexyl-2-hydroxybenzoate ChemComp-KJU: 6-chloro-2H-1,4-benzoxazin-3(4H)-one / 6-クロロ-2H-1,4-ベンゾオキサジン-3(4H)-オン ChemComp-TGX: 7-methyl-2H-1,4-benzothiazin-3(4H)-one ChemComp-XM0: INDAN-2-AMINE / 2-アミノインダン ChemComp-GVG: 3-METHYL-4-PHENYL-1H-PYRAZOLE / 3-メチル-4-フェニル-1H-ピラゾ-ル ChemComp-V2Z: 3-PROPYL-5-(3-PYRIDYL)-1H-PYRAZIN-2-ONE / 3-プロピル-5-(3-ピリジニル)ピラジン-2(1H)-オン ChemComp-YPN: 2-[(5-CHLORO-2-PYRIDYL)SULFANYL]ETHANOL ChemComp-6N0: N-(5,5-dioxodibenzothiophen-2-yl)-4,4-difluoro-piperidine-1-carboxamide ChemComp-6N6: 5-(2-thienyl)-1,3,4-thiadiazol-2-amine / 5-(2-チエニル)-2-アミノ-1,3,4-チアジアゾ-ル ChemComp-6NM: 4-[5-[3-(trifluoromethyl)phenyl]-1H-pyrazol-4-yl]pyridine ChemComp-6NF: N-(CYCLOHEXYLMETHYL)-3-(4-PYRIDYL)-1H-PYRAZOL-5-AMINE ChemComp-6N4: 2-(1H-BENZIMIDAZOL-2-YLSULFANYL)ETHANOL / 2-(1H-ベンゾイミダゾ-ル-2-イルチオ)エタノ-ル ChemComp-1P8: 6-bromo-1,3-dihydro-2H-indol-2-one / 6-ブロモインドリン-2-オン ChemComp-6N8: N-(3,3-DIPHENYLPROPYL)PYRROLIDINE-1-CARBOXAMIDE ChemComp-8NY: 5-iodanyl-1H-indazole ChemComp-6NJ: 3-(2-phenylethyl)-1H-indazole ChemComp-6NX: 1-CYCLOHEXYL-3-METHYL-UREA / 1-シクロヘキシル-3-メチル尿素 ChemComp-FCW: 5-cyclohexyl-1,3-dihydroindol-2-one ChemComp-ONR: 4-chloro-2-isoxazol-5-yl-phenol / 2-(イソオキサゾ-ル-5-イル)-4-クロロフェノ-ル ChemComp-OE1: 2-phenyl-N,N-dipropyl-1H-benzimidazole-5-sulfonamide ChemComp-R4N: 4-[(3-chlorophenyl)methyl]-N-[[(3S)-2,3-dihydro-1,4-benzodioxin-3-yl]methyl]-3-oxidanylidene-1,4-benzothiazine-6-carboxamide ChemComp-4UA: 4-[[(2-methoxy-5-methyl-phenyl)sulfonylamino]methyl]-4-phenyl-N-(p-tolylmethyl)piperidine-1-carboxamide ChemComp-Q3B: 1-[3-[5-(7-aminothiazolo[5,4-d]pyrimidin-2-yl)-1-[[(2S)-tetrahydrofuran-2-yl]methyl]imidazol-4-yl]phenyl]-3-(4-methoxyphenyl)urea ChemComp-T5J: 2-(3-fluoro-4-methyl-anilino)-4-methyl-quinolin-5-ol ChemComp-WMR: 5-butyl-8,8-dimethyl-3,6,8,9-tetrahydropyrazolo[3,4-b]thiopyrano[4,3-d]pyridin-1-amine ChemComp-II6: [(1R,3S,5R)-3-(aminomethyl)-5-methyl-cyclohexyl]methanol ChemComp-7GM: (3R)-1-(cyclopropylmethyl)-3-methyl-3-(4-methylsulfanylphenoxy)pyrrolidine ChemComp-5ZM: 5-(4-FLUOROPHENYL)-3,3-DIMETHYL-INDOLIN-2-ONE ChemComp-A0J: 3-BENZYL-3-METHYL-5-(1-METHYLPYRAZOL-4-YL)INDOLIN-2-ONE ChemComp-QYD: N-(4-NITROPHENYL)-2-PHENYL-THIOMORPHOLINE-4-CARBOXAMIDE ChemComp-GZP: 1-(3-PHENYL-1H-PYRAZOL-5-YL)CYCLOPENTANOL ChemComp-8TM: N-[4-(TRIFLUOROMETHYLSULFANYL)PHENYL]QUINAZOLIN-4-AMINE ChemComp-5DQ: N-CYCLOPENTYL-2-[4-(TRIFLUOROMETHYL)PHENYL]-3H-IMIDAZO[4,5-B]PYRIDINE-7-SULFONAMIDE ChemComp-9XZ: 3-(2-methyltetrazol-5-yl)-5-(3-thienyl)pyridin-2-amine ChemComp-HD2: 4-cyclopentyl-N-[(1S,3R)-5-oxidanyl-2-adamantyl]-2-[[(3S)-oxolan-3-yl]amino]pyrimidine-5-carboxamide ChemComp-6TZ: 3-(3-fluorophenyl)-1H-pyrazole / 3-(3-フルオロフェニル)-1H-ピラゾ-ル ChemComp-JQN: 5-[2-(4-methylphenyl)sulfanylethanoyl]-1,3-dihydroindol-2-one ChemComp-DUL: 5-(3-ethylsulfanylphenyl)thiophene-2-carboxamide ChemComp-B7H: 5-(7-fluoranyl-3,3-dimethyl-2-oxidanylidene-1H-indol-5-yl)-4-methyl-1H-pyrazole-3-carbonitrile ChemComp-XQ9: 1-(1-adamantyl)-3-(1-methylsulfonylpiperidin-4-yl)urea ChemComp-LWS: 7-fluoranyl-3,3-dimethyl-5-(1-methylpyrrol-2-yl)-1H-indol-2-one ChemComp-I5T: 4-oxidanylidene-N-[(1S,2R)-2-phenylcyclopropyl]spiro[3H-chromene-2,4'-piperidine]-1'-carboxamide ChemComp-KUF: 7-METHYL-2H-ISOQUINOLIN-1-ONE ChemComp-AUB: 4-[(trans-4-{[(3s,5s,7s)-tricyclo[3.3.1.1~3,7~]dec-1-ylcarbamoyl]amino}cyclohexyl)oxy]benzoic acid / 1-(アダマンタン-1-イル)-3-[4β-(4-カルボキシフェノキシ)シクロヘキサン-1α-イル]尿素 ChemComp-MVJ: 5-cyclohexylspiro[1H-indole-3,4'-oxane]-2-one ChemComp-6NZ: 5-cyclohexyl-3-propyl-1H-pyridin-2-one
由来	homo sapiens (ヒト)
キーワード	HYDROLASE