タイトル | Discovery of cytotoxic dolastatin 10 analogues with N-terminal modifications. |
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ジャーナル・号・ページ | J. Med. Chem., Vol. 57, Page 10527-10543, Year 2014 |
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掲載日 | 2014年11月24日 (構造データの登録日) |
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著者 | Maderna, A. / Doroski, M. / Subramanyam, C. / Porte, A. / Leverett, C.A. / Vetelino, B.C. / Chen, Z. / Risley, H. / Parris, K. / Pandit, J. ...Maderna, A. / Doroski, M. / Subramanyam, C. / Porte, A. / Leverett, C.A. / Vetelino, B.C. / Chen, Z. / Risley, H. / Parris, K. / Pandit, J. / Varghese, A.H. / Shanker, S. / Song, C. / Sukuru, S.C. / Farley, K.A. / Wagenaar, M.M. / Shapiro, M.J. / Musto, S. / Lam, M.H. / Loganzo, F. / O'Donnell, C.J. |
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リンク | J. Med. Chem. / PubMed:25431858 |
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手法 | X線回折 |
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解像度 | 3.11 - 3.5 Å |
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構造データ | PDB-4x1i: Discovery of cytotoxic Dolastatin 10 analogs with N-terminal modifications 手法: X-RAY DIFFRACTION / 解像度: 3.11 Å PDB-4x1k: Discovery of cytotoxic Dolastatin 10 analogs with N-terminal modifications 手法: X-RAY DIFFRACTION / 解像度: 3.5 Å PDB-4x1y: Discovery of cytotoxic Dolastatin 10 analogs with N-terminal modifications 手法: X-RAY DIFFRACTION / 解像度: 3.19 Å PDB-4x20: Discovery of cytotoxic Dolastatin 10 analogs with N-terminal modifications 手法: X-RAY DIFFRACTION / 解像度: 3.5 Å |
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化合物 | ChemComp-LOC: N-[(7S)-1,2,3,10-tetramethoxy-9-oxo-6,7-dihydro-5H-benzo[d]heptalen-7-yl]ethanamide / コルヒチン / 薬剤, 抗炎症剤*YM
ChemComp-3WD: 2-methyl-L-alanyl-N-[(3R,4S,5S)-3-methoxy-1-{(2S)-2-[(1R,2R)-1-methoxy-2-methyl-3-oxo-3-{[(1S)-2-phenyl-1-(1,3-thiazol-2-yl)ethyl]amino}propyl]pyrrolidin-1-yl}-5-methyl-1-oxoheptan-4-yl]-N-methyl-L-valinamide
ChemComp-3WZ: 2-methyl-L-alanyl-N-[(3R,4S,5S)-1-{(2S)-2-[(1R,2R)-3-{[(1S)-1-carboxy-2-phenylethyl]amino}-1-methoxy-2-methyl-3-oxopropyl]pyrrolidin-1-yl}-3-methoxy-5-methyl-1-oxoheptan-4-yl]-N-methyl-L-valinamide
ChemComp-3WV: N,2-dimethyl-L-alanyl-N-[(3R,4S,5S)-1-{(2S)-2-[(1R,2R)-3-{[(1S)-1-carboxy-2-phenylethyl]amino}-1-methoxy-2-methyl-3-oxopropyl]pyrrolidin-1-yl}-3-methoxy-5-methyl-1-oxoheptan-4-yl]-N-methyl-L-valinamide
ChemComp-3WY: 2-methyl-L-prolyl-N-[(3R,4S,5S)-1-{(2S)-2-[(1R,2R)-3-{[(1S)-1-carboxy-2-phenylethyl]amino}-1-methoxy-2-methyl-3-oxopropyl]pyrrolidin-1-yl}-3-methoxy-5-methyl-1-oxoheptan-4-yl]-N-methyl-L-valinamide
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由来 | - rattus norvegicus (ドブネズミ)
- ovis aries (ヒツジ)
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キーワード | STRUCTURAL PROTEIN/INHIBITOR / Binding Sites / Competitive / Cattle / Tumor / Colchicine / Humans / Microtubules / Protein Binding / Protein Conformation / Protein Multimerization / Tubulin / Tubulin Modulators / STRUCTURAL PROTEIN-INHIBITOR complex |
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