タイトル | Host Cofactors and Pharmacologic Ligands Share an Essential Interface in HIV-1 Capsid That Is Lost upon Disassembly. |
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ジャーナル・号・ページ | Plos Pathog., Vol. 10, Page e1004459-e1004459, Year 2014 |
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掲載日 | 2014年7月11日 (構造データの登録日) |
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著者 | Price, A.J. / Jacques, D.A. / McEwan, W.A. / Fletcher, A.J. / Essig, S. / Chin, J.W. / Halambage, U.D. / Aiken, C. / James, L.C. |
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リンク | Plos Pathog. / PubMed:25356722 |
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手法 | X線回折 |
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解像度 | 1.77 - 3 Å |
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構造データ | PDB-4u0a: Hexameric HIV-1 CA in complex with CPSF6 peptide, P6 crystal form 手法: X-RAY DIFFRACTION / 解像度: 2.05 Å PDB-4u0b: Hexamer HIV-1 CA in complex with CPSF6 peptide, P212121 crystal form 手法: X-RAY DIFFRACTION / 解像度: 2.8 Å PDB-4u0c: Hexameric HIV-1 CA in complex with Nup153 peptide, P6 crystal form 手法: X-RAY DIFFRACTION / 解像度: 1.77 Å PDB-4u0d: Hexameric HIV-1 CA in complex with Nup153 peptide, P212121 crystal form 手法: X-RAY DIFFRACTION / 解像度: 3 Å PDB-4u0e: Hexameric HIV-1 CA in complex with PF3450074 手法: X-RAY DIFFRACTION / 解像度: 2.043 Å PDB-4u0f: Hexameric HIV-1 CA in Complex with BI-2 手法: X-RAY DIFFRACTION / 解像度: 2.22 Å |
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化合物 | ChemComp-1B0: N-METHYL-NALPHA-[(2-METHYL-1H-INDOL-3-YL)ACETYL]-N-PHENYL-L-PHENYLALANINAMIDE
ChemComp-3A8: (4S)-4-(4-hydroxyphenyl)-3-phenyl-4,5-dihydropyrrolo[3,4-c]pyrazol-6(1H)-one
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由来 | - human immunodeficiency virus type 1 group m subtype b (ヒト免疫不全ウイルス)
- homo sapiens (ヒト)
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キーワード | VIRAL PROTEIN / Capsid / Complex / Nuclear Pore / FG repeat / Inhibitor |
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