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-Structure paper
タイトル | Targeting human central nervous system protein kinases: An isoform selective p38 alpha MAPK inhibitor that attenuates disease progression in Alzheimer's disease mouse models. |
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ジャーナル・号・ページ | ACS Chem Neurosci, Vol. 6, Page 666-680, Year 2015 |
掲載日 | 2014年8月14日 (構造データの登録日) |
![]() | Roy, S.M. / Grum-Tokars, V.L. / Schavocky, J.P. / Saeed, F. / Staniszewski, A. / Teich, A.F. / Arancio, O. / Bachstetter, A.D. / Webster, S.J. / Van Eldik, L.J. ...Roy, S.M. / Grum-Tokars, V.L. / Schavocky, J.P. / Saeed, F. / Staniszewski, A. / Teich, A.F. / Arancio, O. / Bachstetter, A.D. / Webster, S.J. / Van Eldik, L.J. / Minasov, G. / Anderson, W.F. / Pelletier, J.C. / Watterson, D.M. |
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手法 | X線回折 |
解像度 | 2.06 Å |
構造データ | ![]() PDB-4r3c: |
化合物 | ![]() ChemComp-GG5: ![]() ChemComp-3GF: ![]() ChemComp-CL: ![]() ChemComp-HOH: |
由来 |
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![]() | TRANSFERASE/TRANSFERASE INHIBITOR / Serine/Threonine-protein kinase / Protein Kinase Domain / Transferase / ATP Binding / Phosphorylation / Cytosol / TRANSFERASE-TRANSFERASE INHIBITOR complex |