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-Structure paper
Title | Targeting human central nervous system protein kinases: An isoform selective p38 alpha MAPK inhibitor that attenuates disease progression in Alzheimer's disease mouse models. |
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Journal, issue, pages | ACS Chem Neurosci, Vol. 6, Page 666-680, Year 2015 |
Publish date | Aug 14, 2014 (structure data deposition date) |
Authors | Roy, S.M. / Grum-Tokars, V.L. / Schavocky, J.P. / Saeed, F. / Staniszewski, A. / Teich, A.F. / Arancio, O. / Bachstetter, A.D. / Webster, S.J. / Van Eldik, L.J. ...Roy, S.M. / Grum-Tokars, V.L. / Schavocky, J.P. / Saeed, F. / Staniszewski, A. / Teich, A.F. / Arancio, O. / Bachstetter, A.D. / Webster, S.J. / Van Eldik, L.J. / Minasov, G. / Anderson, W.F. / Pelletier, J.C. / Watterson, D.M. |
External links | ACS Chem Neurosci / PubMed:25676389 |
Methods | X-ray diffraction |
Resolution | 2.06 Å |
Structure data | PDB-4r3c: |
Chemicals | ChemComp-GG5: ChemComp-3GF: ChemComp-CL: ChemComp-HOH: |
Source |
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Keywords | TRANSFERASE/TRANSFERASE INHIBITOR / Serine/Threonine-protein kinase / Protein Kinase Domain / Transferase / ATP Binding / Phosphorylation / Cytosol / TRANSFERASE-TRANSFERASE INHIBITOR complex |