タイトル | Creating a Resistance Model for TGT: The Effect of Mutations on Flexible lin-Benzoguanine Substituents |
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ジャーナル・号・ページ | To be Published |
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掲載日 | 2014年4月28日 (構造データの登録日) |
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著者 | Neeb, M. / Heine, A. / Klebe, G. |
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リンク | PubMedで検索 |
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手法 | X線回折 |
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解像度 | 1.241 - 1.887 Å |
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構造データ | PDB-4q8m: tRNA-Guanine Transglycosylase (TGT) Mutant V262T Apo Structure 手法: X-RAY DIFFRACTION / 解像度: 1.241 Å PDB-4q8n: tRNA-Guanine Transglycosylase (TGT) Mutant V262C Apo Structure 手法: X-RAY DIFFRACTION / 解像度: 1.449 Å PDB-4q8o: tRNA-Guanine Transglycosylase (TGT) Mutant V262T in Complex with 6-Amino-2-{[2-(morpholin-4-yl)ethyl]amino}-1H,7H,8H-imidazo[4,5-g]quinazolin-8-one 手法: X-RAY DIFFRACTION / 解像度: 1.887 Å PDB-4q8p: tRNA-Guanine Transglycosylase (TGT) Mutant V262D in Complex with 6-Amino-2-{[2-(morpholin-4-yl)ethyl]amino}-1H,7H,8H-imidazo[4,5-g]quinazolin-8-one 手法: X-RAY DIFFRACTION / 解像度: 1.45 Å PDB-4q8q: tRNA-Guanine Transglycosylase (TGT) Mutant V262C in Complex with 6-Amino-2-{[2-(morpholin-4-yl)ethyl]amino}-1H,7H,8H-imidazo[4,5-g]quinazolin-8-one 手法: X-RAY DIFFRACTION / 解像度: 1.721 Å |
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化合物 | |
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由来 | - zymomonas mobilis subsp. mobilis (バクテリア)
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キーワード | Transferase/transferase inhibitor / preQ1 / tRNA / Transferase-transferase inhibitor complex / Guanine Exchange Enzyme / Transferase |
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