タイトル | Dithiol amino acids can structurally shape and enhance the ligand-binding properties of polypeptides. |
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ジャーナル・号・ページ | Nat Chem, Vol. 6, Page 1009-1016, Year 2014 |
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掲載日 | 2014年4月24日 (構造データの登録日) |
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著者 | Chen, S. / Gopalakrishnan, R. / Schaer, T. / Marger, F. / Hovius, R. / Bertrand, D. / Pojer, F. / Heinis, C. |
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リンク | Nat Chem / PubMed:25343607 |
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手法 | NMR (溶液) / X線回折 |
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解像度 | 1.75 - 2.26 Å |
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構造データ | PDB-2moa: Solution NMR structure of peptide ImI1 (peak 2) 手法: SOLUTION NMR PDB-4os1: Crystal structure of urokinase-type plasminogen activator (uPA) complexed with bicyclic peptide UK601 (bicyclic 1) 手法: X-RAY DIFFRACTION / 解像度: 2.2 Å PDB-4os2: Crystal structure of urokinase-type plasminogen activator (uPA) complexed with bicyclic peptide UK602 (bicyclic 1) 手法: X-RAY DIFFRACTION / 解像度: 1.79 Å PDB-4os4: Crystal structure of urokinase-type plasminogen activator (uPA) complexed with bicyclic peptide UK603 (bicyclic 1) 手法: X-RAY DIFFRACTION / 解像度: 2 Å PDB-4os5: Crystal structure of urokinase-type plasminogen activator (uPA) complexed with bicyclic peptide UK603 (bicyclic 2) 手法: X-RAY DIFFRACTION / 解像度: 2.26 Å PDB-4os6: Crystal structure of urokinase-type plasminogen activator (uPA) complexed with bicyclic peptide UK604 (bicyclic 2) 手法: X-RAY DIFFRACTION / 解像度: 1.75 Å PDB-4os7: Crystal structure of urokinase-type plasminogen activator (uPA) complexed with bicyclic peptide UK607 (bicyclic) 手法: X-RAY DIFFRACTION / 解像度: 2 Å |
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化合物 | |
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由来 | conus imperialis (ミカドミナシ) homo sapiens (ヒト)
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キーワード | TOXIN / dithiol amino acid / conotoxin / bicyclic peptide / macrocycle / phage display / HYDROLASE/HYDROLASE INHIBITOR / inhibitor / protease / disulfide bridges / cyclization / extracellular / HYDROLASE-HYDROLASE INHIBITOR complex |
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