タイトル | Negative Epistasis and Evolvability in TEM-1 beta-Lactamase--The Thin Line between an Enzyme's Conformational Freedom and Disorder. |
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ジャーナル・号・ページ | J. Mol. Biol., Vol. 427, Page 2396-2409, Year 2015 |
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掲載日 | 2014年2月5日 (構造データの登録日) |
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著者 | Dellus-Gur, E. / Elias, M. / Caselli, E. / Prati, F. / Salverda, M.L. / de Visser, J.A. / Fraser, J.S. / Tawfik, D.S. |
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リンク | J. Mol. Biol. / PubMed:26004540 |
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手法 | X線回折 |
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解像度 | 1.05 - 2.4 Å |
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構造データ | PDB-4op5: Crystal structure of stabilized TEM-1 beta-lactamase variant v.13 carrying R164S mutation 手法: X-RAY DIFFRACTION / 解像度: 1.05 Å PDB-4op8: Room temperature crystal structure of stabilized TEM-1 beta-lactamase variant v.13 carrying G238S mutation 手法: X-RAY DIFFRACTION / 解像度: 1.95 Å PDB-4opq: Room temperature crystal structure of stabilized TEM-1 beta-lactamase variant v.13 carrying R164S/G238S mutations 手法: X-RAY DIFFRACTION / 解像度: 1.7 Å PDB-4opr: Crystal structure of stabilized TEM-1 beta-lactamase variant v.13 carrying G238S mutation 手法: X-RAY DIFFRACTION / 解像度: 1.45 Å PDB-4opy: Room temperature crystal structure of stabilized TEM-1 beta-lactamase variant v.13 carrying R164S mutation 手法: X-RAY DIFFRACTION / 解像度: 1.75 Å PDB-4opz: Crystal structure of stabilized TEM-1 beta-lactamase variant v.13 carrying G238S mutation in complex with boron-based inhibitor EC25 手法: X-RAY DIFFRACTION / 解像度: 1.45 Å PDB-4oq0: Crystal structure of stabilized TEM-1 beta-lactamase variant v.13 carrying R164S/G238S mutation in complex with boron-based inhibitor EC25 手法: X-RAY DIFFRACTION / 解像度: 1.42 Å PDB-4oqg: Crystal structure of TEM-1 beta-lactamase in complex with boron-based inhibitor EC25 手法: X-RAY DIFFRACTION / 解像度: 2.4 Å PDB-4oqh: Crystal structure of stabilized TEM-1 beta-lactamase variant v.13 carrying R164S mutation in complex with boron-based inhibitor EC25 手法: X-RAY DIFFRACTION / 解像度: 1.7 Å PDB-4oqi: Crystal structure of stabilized TEM-1 beta-lactamase variant v.13 carrying R164S/G238S mutations 手法: X-RAY DIFFRACTION / 解像度: 1.13 Å |
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化合物 | ChemComp-2UL: 3-[(2R)-2-{[(2R)-2-amino-2-phenylacetyl]amino}-2-(dihydroxyboranyl)ethyl]benzoic acid
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由来 | ![](img/tx_bacteria.gif) escherichia coli (大腸菌)
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キーワード | HYDROLASE / Beta-lactamase / Beta-lactamas / hydrolase/hydrolase inhibitor / hydrolase-hydrolase inhibitor complex / Beta-lctamase |
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