タイトル | Acetyl-lysine Binding Site of Bromodomain-Containing Protein 4 (BRD4) Interacts with Diverse Kinase Inhibitors. |
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ジャーナル・号・ページ | Acs Chem. Biol., Vol. 9, Page 1160-1171, Year 2014 |
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掲載日 | 2013年12月24日 (構造データの登録日) |
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著者 | Ember, S.W. / Zhu, J.Y. / Olesen, S.H. / Martin, M.P. / Becker, A. / Berndt, N. / Georg, G.I. / Schonbrunn, E. |
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リンク | Acs Chem. Biol. / PubMed:24568369 |
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手法 | X線回折 |
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解像度 | 1.34 - 2 Å |
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構造データ | PDB-4o70: Crystal structure of the first bromodomain of human BRD4 in complex with DINACICLIB 手法: X-RAY DIFFRACTION / 解像度: 1.55 Å PDB-4o71: Crystal structure of the first bromodomain of human BRD4 in complex with FLAVOPIRIDOL 手法: X-RAY DIFFRACTION / 解像度: 1.36 Å PDB-4o72: Crystal structure of the first bromodomain of human BRD4 in complex with NU7441 手法: X-RAY DIFFRACTION / 解像度: 1.4 Å PDB-4o74: Crystal structure of the first bromodomain of human BRD4 in complex with BI 2536 手法: X-RAY DIFFRACTION / 解像度: 1.45 Å PDB-4o75: Crystal structure of the first bromodomain of human BRD4 in complex with FOSTAMATINIB 手法: X-RAY DIFFRACTION / 解像度: 1.55 Å PDB-4o76: Crystal structure of the first bromodomain of human BRD4 in complex with TG101209 手法: X-RAY DIFFRACTION / 解像度: 1.7 Å PDB-4o77: Crystal structure of the first bromodomain of human BRD4 in complex with SB 202190 手法: X-RAY DIFFRACTION / 解像度: 2 Å PDB-4o78: Crystal structure of the first bromodomain of human BRD4 in complex with GW612286X 手法: X-RAY DIFFRACTION / 解像度: 1.34 Å PDB-4o7a: Crystal structure of the first bromodomain of human BRD4 in complex with SB-409514 手法: X-RAY DIFFRACTION / 解像度: 1.34 Å PDB-4o7b: Crystal structure of the first bromodomain of human BRD4 in complex with SB-284847-BT 手法: X-RAY DIFFRACTION / 解像度: 1.5 Å PDB-4o7c: Crystal structure of the first bromodomain of human BRD4 in complex with SB-614067-R 手法: X-RAY DIFFRACTION / 解像度: 1.55 Å PDB-4o7e: Crystal structure of the first bromodomain of human BRD4 in complex with SB-610251-B 手法: X-RAY DIFFRACTION / 解像度: 1.85 Å PDB-4o7f: Crystal structure of the first bromodomain of human BRD4 in complex with SB-251527 手法: X-RAY DIFFRACTION / 解像度: 1.8 Å PDB-4ps5: Crystal structure of the first bromodomain of human BRD4 in complex with TG101348 手法: X-RAY DIFFRACTION / 解像度: 1.4 Å |
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化合物 | ChemComp-1QK: 3-[({3-ethyl-5-[(2S)-2-(2-hydroxyethyl)piperidin-1-yl]pyrazolo[1,5-a]pyrimidin-7-yl}amino)methyl]-1-hydroxypyridinium
ChemComp-2R4: 8-(dibenzo[b,d]thiophen-4-yl)-2-(morpholin-4-yl)-4H-chromen-4-one / NU-7441
ChemComp-R78: 4-{[(7R)-8-cyclopentyl-7-ethyl-5-methyl-6-oxo-5,6,7,8-tetrahydropteridin-2-yl]amino}-3-methoxy-N-(1-methylpiperidin-4-yl)benzamide / BI-2536
ChemComp-2RC: [6-({5-fluoro-2-[(3,4,5-trimethoxyphenyl)amino]pyrimidin-4-yl}amino)-2,2-dimethyl-3-oxo-2,3-dihydro-4H-pyrido[3,2-b][1,4]oxazin-4-yl]methyl dihydrogen phosphate / フォスタマチニブ / 薬剤, 阻害剤*YM
ChemComp-1M3: N-tert-butyl-3-[(5-methyl-2-{[4-(4-methylpiperazin-1-yl)phenyl]amino}pyrimidin-4-yl)amino]benzenesulfonamide
ChemComp-SAV: N~4~-(3-methyl-1H-indazol-6-yl)-N~2~-(3,4,5-trimethoxyphenyl)pyrimidine-2,4-diamine
ChemComp-2RK: 4-[(5Z)-5-(1-nitroso-2,3-dihydro-5H-inden-5-ylidene)-2-(piperidin-4-yl)-3,5-dihydro-4H-imidazol-4-ylidene]-1,4-dihydropyridine
ChemComp-2TA: N-tert-butyl-3-{[5-methyl-2-({4-[2-(pyrrolidin-1-yl)ethoxy]phenyl}amino)pyrimidin-4-yl]amino}benzenesulfonamide / TG-101348 / 薬剤, 抗がん剤*YM
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由来 | homo sapiens (ヒト)
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キーワード | TRANSCRIPTION/INHIBITOR / BROMODOMAIN / CAP / HUNK1 / MCAP / PROTEIN BINDING-INHIBITOR COMPLEX / MITOTIC CHROMOSOME ASSOCIATED PROTEIN / CELL CYCLE / INHIBITOR / TRANSCRIPTION-INHIBITOR complex / TRANSCRIPTION/TRANSCRIPTION INHIBITOR / TRANSCRIPTION-TRANSCRIPTION INHIBITOR complex |
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