EMDB/PDB/SASBDBから引用されている文献のデータベース

キーワード
構造解析手法	All X線回折 NMR 電子顕微鏡小角散乱中性子線回折線維回折粉末回折赤外分光 EPR FRET 理論モデルハイブリッド
著者・登録者
ジャーナル
IF	>30 >20 >10 >5 all

タイトル	Crystallographic fragment screening and structure-based optimization yields a new class of influenza endonuclease inhibitors.
ジャーナル・号・ページ	Acs Chem. Biol., Vol. 8, Page 2501-2508, Year 2013
掲載日	2013年7月11日 (構造データの登録日)
著者	Bauman, J.D. / Patel, D. / Baker, S.F. / Vijayan, R.S. / Xiang, A. / Parhi, A.K. / Martinez-Sobrido, L. / Lavoie, E.J. / Das, K. / Arnold, E.
リンク	Acs Chem. Biol. / PubMed:23978130
手法	X線回折
解像度	1.4 - 2.502 Å
構造データ	PDB-4ln7: 5,6-bis(4-fluorophenyl)-3-hydroxy-2,5-dihydropyridin-2-one bound to influenza 2009 pH1N1 endonuclease 手法: X-RAY DIFFRACTION / 解像度: 1.73 Å PDB-4m4q: 6-(4-fluorophenyl)-3-hydroxy-5-[4-(1H-1,2,3,4-tetrazol-5-yl)phenyl] -1,2-dihydropyridin-2-one bound to influenza 2009 H1N1 endonuclease 手法: X-RAY DIFFRACTION / 解像度: 2.502 Å PDB-4m5o: 3-HYDROXY-6-PHENYL-1,2-DIHYDROPYRIDIN-2-ONE bound to influenza 2009 H1N1 endonuclease 手法: X-RAY DIFFRACTION / 解像度: 2 Å PDB-4m5q: High-resolution apo influenza 2009 H1N1 endonuclease structure 手法: X-RAY DIFFRACTION / 解像度: 1.534 Å PDB-4m5r: High-resolution influenza 2009 H1N1 endonuclease bound to 4-(1H-IMIDAZOL-1-YL)PHENOL 手法: X-RAY DIFFRACTION / 解像度: 1.4 Å PDB-4m5v: Influenza 2009 H1N1 endonuclease with 100 millimolar calcium 手法: X-RAY DIFFRACTION / 解像度: 1.8 Å PDB-4mk1: 5-bromopyridine-2,3-diol bound to influenza 2009 pH1N1 endonuclease 手法: X-RAY DIFFRACTION / 解像度: 1.85 Å PDB-4mk2: 3-(5-hydroxy-6-oxo-1,6-dihydropyridin-3-yl)benzonitrile bound to influenza 2009 pH1N1 endonuclease 手法: X-RAY DIFFRACTION / 解像度: 1.85 Å PDB-4mk5: 6-(3-methoxyphenyl)pyridine-2,3-diol bound to influenza 2009 pH1N1 endonuclease 手法: X-RAY DIFFRACTION / 解像度: 1.9 Å
化合物	ChemComp-MN: Unknown entry ChemComp-EDO: 1,2-ETHANEDIOL / エチレングリコ-ル ChemComp-SO4: SULFATE ION / 硫酸ジアニオン ChemComp-1ZQ: 5,6-bis(4-fluorophenyl)pyridine-2,3-diol ChemComp-MG: Unknown entry / マグネシウムジカチオン ChemComp-HOH: WATER ChemComp-21A: 6-(4-fluorophenyl)-5-[4-(1H-tetrazol-5-yl)phenyl]pyridine-2,3-diol ChemComp-X48: 3-hydroxy-6-phenylpyridin-2(5H)-one ChemComp-MSR: 4-(1H-IMIDAZOL-1-YL)PHENOL / 4-(1H-イミダゾ-ル-1-イル)フェノ-ル ChemComp-CA: Unknown entry / カルシウムジカチオン ChemComp-27Y: 5-bromo-3-hydroxypyridin-2(1H)-one ChemComp-28B: 3-(5-hydroxy-6-oxo-1,6-dihydropyridin-3-yl)benzonitrile ChemComp-28A: 3-hydroxy-6-(3-methoxyphenyl)pyridin-2(5H)-one
由来	influenza a virus (a/lima/wrair1695p/2009(h1n1)) (A型インフルエンザウイルス)
キーワード	RNA BINDING PROTEIN/INHIBITOR / CAP-SNATCHING / RNA BINDING PROTEIN-INHIBITOR / RNA BINDING PROTEIN-INHIBITOR complex / RNA BINDING PROTEIN