EMDB/PDB/SASBDBから引用されている文献のデータベース

キーワード
構造解析手法	All X線回折 NMR 電子顕微鏡小角散乱中性子線回折線維回折粉末回折赤外分光 EPR FRET 理論モデルハイブリッド
著者・登録者
ジャーナル
IF	>30 >20 >10 >5 all

タイトル	K-Ras(G12C) inhibitors allosterically control GTP affinity and effector interactions.
ジャーナル・号・ページ	Nature, Vol. 503, Page 548-551, Year 2013
掲載日	2013年6月17日 (構造データの登録日)
著者	Ostrem, J.M. / Peters, U. / Sos, M.L. / Wells, J.A. / Shokat, K.M.
リンク	Nature / PubMed:24256730
手法	X線回折
解像度	1.29 - 2.151 Å
構造データ	PDB-4l8g: Crystal Structure of K-Ras G12C, GDP-bound 手法: X-RAY DIFFRACTION / 解像度: 1.521 Å PDB-4l9s: Crystal Structure of H-Ras G12C, GDP-bound 手法: X-RAY DIFFRACTION / 解像度: 1.606 Å PDB-4l9w: Crystal Structure of H-Ras G12C, GMPPNP-bound 手法: X-RAY DIFFRACTION / 解像度: 1.952 Å PDB-4lpk: Crystal Structure of K-Ras WT, GDP-bound 手法: X-RAY DIFFRACTION / 解像度: 1.5 Å PDB-4lrw: Crystal Structure of K-Ras G12C (cysteine-light), GDP-bound 手法: X-RAY DIFFRACTION / 解像度: 2.151 Å PDB-4luc: Crystal Structure of small molecule disulfide 6 bound to K-Ras G12C 手法: X-RAY DIFFRACTION / 解像度: 1.29 Å PDB-4lv6: Crystal Structure of small molecule disulfide 4 covalently bound to K-Ras G12C 手法: X-RAY DIFFRACTION / 解像度: 1.5 Å PDB-4lyf: Crystal Structure of small molecule vinylsulfonamide 8 covalently bound to K-Ras G12C 手法: X-RAY DIFFRACTION / 解像度: 1.568 Å PDB-4lyh: Crystal Structure of small molecule vinylsulfonamide 9 covalently bound to K-Ras G12C 手法: X-RAY DIFFRACTION / 解像度: 1.371 Å PDB-4lyj: Crystal Structure of small molecule vinylsulfonamide 9 covalently bound to K-Ras G12C, alternative space group 手法: X-RAY DIFFRACTION / 解像度: 1.927 Å PDB-4m1o: Crystal Structure of small molecule vinylsulfonamide 7 covalently bound to K-Ras G12C 手法: X-RAY DIFFRACTION / 解像度: 1.571 Å PDB-4m1s: Crystal Structure of small molecule vinylsulfonamide 13 covalently bound to K-Ras G12C 手法: X-RAY DIFFRACTION / 解像度: 1.552 Å PDB-4m1t: Crystal Structure of small molecule vinylsulfonamide 14 covalently bound to K-Ras G12C 手法: X-RAY DIFFRACTION / 解像度: 1.703 Å PDB-4m1w: Crystal Structure of small molecule vinylsulfonamide covalently bound to K-Ras G12C 手法: X-RAY DIFFRACTION / 解像度: 1.58 Å PDB-4m1y: Crystal Structure of small molecule vinylsulfonamide 15 covalently bound to K-Ras G12C 手法: X-RAY DIFFRACTION / 解像度: 1.491 Å PDB-4m21: Crystal Structure of small molecule acrylamide 11 covalently bound to K-Ras G12C 手法: X-RAY DIFFRACTION / 解像度: 1.94 Å PDB-4m22: Crystal Structure of small molecule acrylamide 16 covalently bound to K-Ras G12C 手法: X-RAY DIFFRACTION / 解像度: 2.09 Å
化合物	ChemComp-GDP: GUANOSINE-5'-DIPHOSPHATE / GDP / GDP, エネルギー貯蔵分子YM ChemComp-MG: Unknown entry / マグネシウムジカチオン ChemComp-NA: Unknown entry / ナトリウムカチオン ChemComp-HOH: WATER ChemComp-CA: Unknown entry / カルシウムジカチオン ChemComp-GNP: PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER / Gpp(NH)p / GppNHp, GMPPNP, エネルギー貯蔵分子類似体YM ChemComp-20G: N-{1-[(2,4-dichlorophenoxy)acetyl]piperidin-4-yl}-4-sulfanylbutanamide / 阻害剤YM ChemComp-20H: 1-[(2,4-dichlorophenoxy)acetyl]-N-(2-sulfanylethyl)piperidine-4-carboxamide ChemComp-21C: N-{1-[N-(4,5-dichloro-2-hydroxyphenyl)glycyl]piperidin-4-yl}ethanesulfonamide ChemComp-SO4: SULFATE ION / 硫酸ジアニオン ChemComp-21F: N-{1-[N-(4-chloro-5-iodo-2-methoxyphenyl)glycyl]piperidin-4-yl}ethanesulfonamide ChemComp-21J: N-(1-{[(5,7-dichloro-2,2-dimethyl-1,3-benzodioxol-4-yl)oxy]acetyl}piperidin-4-yl)ethanesulfonamide ChemComp-21K: N-{1-[N-(2,4-dichlorophenyl)glycyl]piperidin-4-yl}ethanesulfonamide ChemComp-21M: N-{1-[(2,4-dichlorophenoxy)acetyl]piperidin-4-yl}ethanesulfonamide ChemComp-21R: N-{1-[N-(4,5-dichloro-2-ethylphenyl)glycyl]piperidin-4-yl}ethanesulfonamide ChemComp-21S: N-{1-[N-(5,7-dichloro-2,1,3-benzothiadiazol-4-yl)glycyl]piperidin-4-yl}ethanesulfonamide ChemComp-21Y: 1-(4-{[(4,5-dichloro-2-methoxyphenyl)amino]acetyl}piperazin-1-yl)propan-1-one ChemComp-22C*: 1-{4-[(2,4-dichlorophenoxy)acetyl]piperazin-1-yl}propan-1-one
由来	homo sapiens (ヒト)
キーワード	SIGNALING PROTEIN / GTPase / activating mutant / GDP bound / SIGNALING PROTEIN/INHIBITOR / SIGNALING PROTEIN-INHIBITOR complex / small molecule inhibitor / covalent binder