EMDB/PDB/SASBDBから引用されている文献のデータベース

キーワード
構造解析手法	All X線回折 NMR 電子顕微鏡小角散乱中性子線回折線維回折粉末回折赤外分光 EPR FRET 理論モデルハイブリッド
著者・登録者
ジャーナル
IF	>30 >20 >10 >5 all

タイトル	Development of Selective, Potent RabGGTase Inhibitors
ジャーナル・号・ページ	J. Med. Chem., Vol. 55, Page 8330-8340, Year 2012
掲載日	2012年8月28日 (構造データの登録日)
著者	Stigter, E.A. / Guo, Z. / Bon, R.S. / Wu, Y.W. / Choidas, A. / Wolf, A. / Menninger, S. / Waldmann, H. / Blankenfeldt, W. / Goody, R.S.
リンク	J. Med. Chem. / PubMed:22963166
手法	X線回折
解像度	1.95 - 2.75 Å
構造データ	PDB-4gtm: FTase in complex with BMS analogue 11 手法: X-RAY DIFFRACTION / 解像度: 2.2 Å PDB-4gto: FTase in complex with BMS analogue 14 手法: X-RAY DIFFRACTION / 解像度: 2.15 Å PDB-4gtp: FTase in complex with BMS analogue 16 手法: X-RAY DIFFRACTION / 解像度: 2.75 Å PDB-4gtq: FTase in complex with BMS analogue 12 手法: X-RAY DIFFRACTION / 解像度: 2.6 Å PDB-4gtr: FTase in complex with BMS analogue 13 手法: X-RAY DIFFRACTION / 解像度: 2.2 Å PDB-4gts: Engineered RabGGTase in complex with BMS analogue 16 手法: X-RAY DIFFRACTION / 解像度: 2.45 Å PDB-4gtt: Engineered RabGGTase in complex with BMS analogue 12 手法: X-RAY DIFFRACTION / 解像度: 2.05 Å PDB-4gtv: Engineered RabGGTase in complex with BMS analogue 13 手法: X-RAY DIFFRACTION / 解像度: 1.95 Å
化合物	ChemComp-ZN: Unknown entry ChemComp-FPP: FARNESYL DIPHOSPHATE / ファルネシル二りん酸 ChemComp-7TM: 4-({(3R)-7-cyano-4-[(4-methoxyphenyl)sulfonyl]-1-[(1-methyl-1H-imidazol-5-yl)methyl]-2,3,4,5-tetrahydro-1H-1,4-benzodiazepin-3-yl}methyl)phenyl hexylcarbamate ChemComp-DMS: DIMETHYL SULFOXIDE / 2-チアプロパン2-オキシド / DMSO, 沈殿剤YM ChemComp-HOH: WATER ChemComp-7TO: 4-({(3R)-7-cyano-4-[(4-methoxyphenyl)sulfonyl]-1-[(1-methyl-1H-imidazol-5-yl)methyl]-2,3,4,5-tetrahydro-1H-1,4-benzodiazepin-3-yl}methyl)phenyl trifluoromethanesulfonate ChemComp-7TP: 5-{(3R)-3-(4-hydroxybenzyl)-4-[(4-methoxyphenyl)sulfonyl]-1-[(1-methyl-1H-imidazol-5-yl)methyl]-2,3,4,5-tetrahydro-1H-1,4-benzodiazepin-7-yl}furan-2-carbaldehyde / 5-[(3R)-1-(1-メチル-1H-イミダゾ-ル-5-イルメチル)-3β-(4-ヒドロキシベンジル)-4-[(4-(以下略) ChemComp-7TQ: 4-({(3R)-7-cyano-4-[(4-methoxyphenyl)sulfonyl]-1-[(1-methyl-1H-imidazol-5-yl)methyl]-2,3,4,5-tetrahydro-1H-1,4-benzodiazepin-3-yl}methyl)phenyl benzylcarbamate / N-ベンジルカルバミド酸4-[[(3R)-7-シアノ-1-(1-メチル-1H-イミダゾ-ル-5-イルメチル)-4-[((以下略) ChemComp-7TR: 4-({(3R)-7-cyano-4-[(4-methoxyphenyl)sulfonyl]-1-[(1-methyl-1H-imidazol-5-yl)methyl]-2,3,4,5-tetrahydro-1H-1,4-benzodiazepin-3-yl}methyl)phenyl diethylcarbamate / N,N-ジエチルカルバミド酸4-[[(3R)-7-シアノ-1-(1-メチル-1H-イミダゾ-ル-5-イルメチル)-4-(以下略) ChemComp-CA*: Unknown entry / カルシウムジカチオン
由来	rattus norvegicus (ドブネズミ)
キーワード	TRANSFERASE/TRANSFERASE INHIBITOR / protein prenylation / inhibitor / TRANSFERASE-TRANSFERASE INHIBITOR complex