タイトル | Crystal Structures of HIV-1 gp120 Envelope Glycoprotein in Complex with NBD Analogues That Target the CD4-Binding Site. |
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ジャーナル・号・ページ | Plos One, Vol. 9, Page e85940-e85940, Year 2014 |
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掲載日 | 2012年2月23日 (構造データの登録日) |
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著者 | Kwon, Y.D. / Lalonde, J.M. / Yang, Y. / Elban, M.A. / Sugawara, A. / Courter, J.R. / Jones, D.M. / Smith, A.B. / Debnath, A.K. / Kwong, P.D. |
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リンク | Plos One / PubMed:24489681 |
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手法 | X線回折 |
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解像度 | 1.94 - 2.5 Å |
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構造データ | PDB-4dvr: Crystal structure of YU2 gp120 core in complex with Fab 48d and NBD-557 手法: X-RAY DIFFRACTION / 解像度: 2.5 Å PDB-4dvs: Crystal structure of clade A/E 93TH057 HIV-1 gp120 core in complex with NBD-557 手法: X-RAY DIFFRACTION / 解像度: 2.1 Å PDB-4dvt: Crystal structure of clade A/E 93TH057 HIV-1 gp120 core in complex with AS-II-37 手法: X-RAY DIFFRACTION / 解像度: 2.4 Å PDB-4dvv: Crystal structure of clade A/E 93TH057 HIV-1 gp120 core in complex with AS-I-261 手法: X-RAY DIFFRACTION / 解像度: 1.94 Å PDB-4dvw: Crystal structure of clade A/E 93TH057 HIV-1 gp120 core in complex with MAE-II-167 手法: X-RAY DIFFRACTION / 解像度: 2.2 Å PDB-4dvx: Crystal structure of clade A/E 93TH057 HIV-1 gp120 core in complex with MAE-II-188 手法: X-RAY DIFFRACTION / 解像度: 2.4 Å |
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化合物 | ChemComp-0LY: N-(4-bromophenyl)-N'-(2,2,6,6-tetramethylpiperidin-4-yl)ethanediamide / NBD-557
ChemComp-EPE: 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID / HEPES / pH緩衝剤*YM
ChemComp-0LZ: N-(4-chloro-3-fluorophenyl)-N'-[(1S)-1,2,3,4-tetrahydroisoquinolin-1-ylmethyl]ethanediamide
ChemComp-0M1: N-{[(4S,5S)-5-(aminomethyl)-2,2-dimethyl-1,3-dioxolan-4-yl]methyl}-N'-(4-chloro-3-fluorophenyl)ethanediamide
ChemComp-0M4: N-(4-chloro-3-fluorophenyl)-N'-[(3aS,6aS)-hexahydrocyclopenta[c]pyrrol-3a(1H)-ylmethyl]ethanediamide
ChemComp-0M5: N-(4-chloro-3-fluorophenyl)-N'-{[(3R)-1-cyclopropylpyrrolidin-3-yl]methyl}ethanediamide
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由来 | - human immunodeficiency virus type 1 group m subtype b (isolate yu-2) (ヒト免疫不全ウイルス)
- homo sapiens (ヒト)
- human immunodeficiency virus 1 (ヒト免疫不全ウイルス)
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キーワード | IMMUNE SYSTEM/TRANSCRIPTION INHIBITOR / HIV-1 gp120 / CD4 binding site / NBD-557 / IMMUNE SYSTEM-TRANSCRIPTION INHIBITOR complex / viral protein/transcription inhibitor / small molecule inhibitor / viral protein-transcription inhibitor complex / AS-II-37 / AS-I-261 / MAE-II-167 / MAE-II-188 |
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