EMDB/PDB/SASBDBから引用されている文献のデータベース

キーワード
構造解析手法	All X線回折 NMR 電子顕微鏡小角散乱中性子線回折線維回折粉末回折赤外分光 EPR FRET 理論モデルハイブリッド
著者・登録者
ジャーナル
IF	>30 >20 >10 >5 all

タイトル	Virtual screening and experimental validation reveal novel small-molecule inhibitors of 14-3-3 protein-protein interactions.
ジャーナル・号・ページ	Chem. Commun. (Camb. ), Vol. 49, Page 8468-8470, Year 2013
掲載日	2011年7月20日 (構造データの登録日)
著者	Thiel, P. / Roglin, L. / Meissner, N. / Hennig, S. / Kohlbacher, O. / Ottmann, C.
リンク	Chem. Commun. (Camb. ) / PubMed:23939230
手法	X線回折
解像度	1.4 - 1.8 Å
構造データ	PDB-3t0l: Small-molecule inhibitors of 14-3-3 protein-protein interactions from virtual screening 手法: X-RAY DIFFRACTION / 解像度: 1.6 Å PDB-3t0m: Small-molecule inhibitors of 14-3-3 protein-protein interactions from virtual screening 手法: X-RAY DIFFRACTION / 解像度: 1.62 Å PDB-4dhm: Small-molecule inhibitors of 14-3-3 protein-protein interactions from virtual screening 手法: X-RAY DIFFRACTION / 解像度: 1.7 Å PDB-4dhn: Small-molecule inhibitors of 14-3-3 protein-protein interactions from virtual screening 手法: X-RAY DIFFRACTION / 解像度: 1.8 Å PDB-4dho: Small-molecule inhibitors of 14-3-3 protein-protein interactions from virtual screening 手法: X-RAY DIFFRACTION / 解像度: 1.7 Å PDB-4dhp: Small-molecule inhibitors of 14-3-3 protein-protein interactions from virtual screening 手法: X-RAY DIFFRACTION / 解像度: 1.75 Å PDB-4dhq: Small-molecule inhibitors of 14-3-3 protein-protein interactions from virtual screening 手法: X-RAY DIFFRACTION / 解像度: 1.75 Å PDB-4dhr: Small-molecule inhibitors of 14-3-3 protein-protein interactions from virtual screening 手法: X-RAY DIFFRACTION / 解像度: 1.4 Å PDB-4dhs: Small-molecule inhibitors of 14-3-3 protein-protein interactions from virtual screening 手法: X-RAY DIFFRACTION / 解像度: 1.74 Å PDB-4dht: Small-molecule inhibitors of 14-3-3 protein-protein interactions from virtual screening 手法: X-RAY DIFFRACTION / 解像度: 1.8 Å PDB-4dhu: Small-molecule inhibitors of 14-3-3 protein-protein interactions from virtual screening 手法: X-RAY DIFFRACTION / 解像度: 1.67 Å
化合物	ChemComp-1CT: [2-(2-oxo-2-{[2-(trifluoromethyl)phenyl]amino}ethoxy)phenyl]phosphonic acid ChemComp-GOL: GLYCEROL / グリセロ-ル ChemComp-CL: Unknown entry / クロリド ChemComp-MG: Unknown entry / マグネシウムジカチオン ChemComp-HOH: WATER ChemComp-2CT: (2-{2-[(2,5-dimethoxyphenyl)amino]-2-oxoethoxy}phenyl)phosphonic acid ChemComp-0KB: [2-(2-oxo-2-{[3-(trifluoromethyl)phenyl]amino}ethoxy)phenyl]phosphonic acid ChemComp-0KC: {2-[2-(cyclopentylamino)-2-oxoethoxy]phenyl}phosphonic acid ChemComp-Y09: (2-{2-[(3-methoxyphenyl)amino]-2-oxoethoxy}phenyl)phosphonic acid ChemComp-Y07: [2-(2-{[2-chloro-5-(trifluoromethyl)phenyl]amino}-2-oxoethoxy)phenyl]phosphonic acid ChemComp-Y06: (2-{2-[(3-chlorophenyl)amino]-2-oxoethoxy}phenyl)phosphonic acid ChemComp-Y04: (2-{2-[(2-chlorophenyl)amino]-2-oxoethoxy}phenyl)phosphonic acid ChemComp-Y03: (2-{2-[(3,5-dichlorophenyl)amino]-2-oxoethoxy}phenyl)phosphonic acid ChemComp-0KG: {2-[2-(cyclohexylamino)-2-oxoethoxy]phenyl}phosphonic acid ChemComp-0KH: (2-{2-[(2,3-dichlorophenyl)amino]-2-oxoethoxy}phenyl)phosphonic acid
由来	homo sapiens (ヒト)
キーワード	PROTEIN BINDING/INHIBITOR / Helical protein / Adapter protein / Protein-protein interaction / PROTEIN BINDING-INHIBITOR complex / PHOSPHOPROTEIN BINDING