タイトル | Love-Hate Ligands for High Resolution Analysis of Strain in Ultra-Stable Protein/Small Molecule Interaction. |
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ジャーナル・号・ページ | Bioorg. Med. Chem., Vol. 22, Page 5476-, Year 2014 |
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掲載日 | 2014年2月6日 (構造データの登録日) |
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著者 | Fairhead, M. / Shen, D. / Chan, L.K.M. / Lowe, E.D. / Donohoe, T.J. / Howarth, M. |
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リンク | Bioorg. Med. Chem. / PubMed:25128469 |
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手法 | X線回折 |
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解像度 | 1.06 - 1.64 Å |
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構造データ | PDB-4cpe: Wild-type streptavidin in complex with love-hate ligand 1 (LH1) 手法: X-RAY DIFFRACTION / 解像度: 1.06 Å PDB-4cpf: Wild-type streptavidin in complex with love-hate ligand 3 (LH3) 手法: X-RAY DIFFRACTION / 解像度: 1.14 Å PDB-4cph: trans-divalent streptavidin with love-hate ligand 4 手法: X-RAY DIFFRACTION / 解像度: 1.64 Å PDB-4cpi: streptavidin A86D mutant with love-hate ligand 4 手法: X-RAY DIFFRACTION / 解像度: 1.54 Å |
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化合物 | ChemComp-LUV: (3aS,4S,6aR)-2-oxo-hexahydro-1H-thieno[3,4- d]imidazolidin-4-yl]-N-{2-[(2,6- diphenylphenyl)formamido]ethyl}pentanamide
ChemComp-LH3: methyl 4-(2-{5-[(3aS,4S,6aR)-2-oxo-hexahydro-1H- thieno[3,4-d]imidazolidin-4-yl]pentanehydrazido}-3- [4-(methoxycarbonyl)phenyl]phenyl)benzoate
ChemComp-LH4: 5-[(3aS,4S,6aR)-2-oxo-hexahydro-1H-thieno[3,4- d]imidazolidin-4-yl]-N'-{2,6-bis[4-(morpholine-4- sulfonyl)phenyl]phenyl}pentanehydrazide
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由来 | streptomyces avidinii (バクテリア)
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キーワード | BIOTIN-BINDING PROTEIN / AVIDIN / BIOTIN / STRAIN / BIOTINYLATED / STERIC CLASH / STRAINED / HINDERED / FORCE / LIGAND SERIES / AFFINITY / BIOTIN BINDING PROTEIN |
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