タイトル | Structural and Molecular Basis of Znrf3/Rnf43 Transmembrane Ubiquitin Ligase Inhibition by the Wnt Agonist R-Spondin. |
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ジャーナル・号・ページ | Nat. Commun., Vol. 4, Page 2787-, Year 2013 |
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掲載日 | 2013年9月29日 (構造データの登録日) |
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著者 | Zebisch, M. / Xu, Y. / Krastev, C. / Macdonald, B.T. / Chen, M. / Gilbert, R.J.C. / He, X. / Jones, E.Y. |
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リンク | Nat. Commun. / PubMed:24225776 |
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手法 | X線回折 |
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解像度 | 1.6 - 3.1 Å |
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構造データ | PDB-4c84: zebrafish ZNRF3 ectodomain crystal form I 手法: X-RAY DIFFRACTION / 解像度: 1.6 Å PDB-4c85: zebrafish ZNRF3 ectodomain crystal form II 手法: X-RAY DIFFRACTION / 解像度: 2.5 Å PDB-4c86: mouse ZNRF3 ectodomain crystal form I 手法: X-RAY DIFFRACTION / 解像度: 2 Å PDB-4c8a: mouse ZNRF3 ectodomain crystal form II 手法: X-RAY DIFFRACTION / 解像度: 2.7 Å PDB-4c8c: mouse ZNRF3 ectodomain crystal form III 手法: X-RAY DIFFRACTION / 解像度: 2.4 Å PDB-4c8f: mouse ZNRF3 ectodomain crystal form IV 手法: X-RAY DIFFRACTION / 解像度: 2.69 Å PDB-4c8p: mouse ZNRF3 ectodomain crystal form V, disulfide-bridged S90C variant 手法: X-RAY DIFFRACTION / 解像度: 2.1 Å PDB-4c8t: Xenopus ZNRF3 ectodomain crystal form I 手法: X-RAY DIFFRACTION / 解像度: 2.4 Å PDB-4c8u: Xenopus ZNRF3 ectodomain crystal form II 手法: X-RAY DIFFRACTION / 解像度: 3.01 Å PDB-4c8v: Xenopus RSPO2 Fu1-Fu2 crystal form I 手法: X-RAY DIFFRACTION / 解像度: 2.2 Å PDB-4c8w: Xenopus RSPO2 Fu1-Fu2 crystal form II 手法: X-RAY DIFFRACTION / 解像度: 3.1 Å PDB-4c99: Mouse ZNRF3 ectodomain in complex with mouse RSPO2 Fu1-Fu2 crystal form I 手法: X-RAY DIFFRACTION / 解像度: 2.8 Å PDB-4c9a: Mouse ZNRF3 ectodomain in complex with Xenopus RSPO2 Fu1-Fu2 (Seleno Met) crystal form I 手法: X-RAY DIFFRACTION / 解像度: 2.4 Å PDB-4c9e: Mouse ZNRF3 ectodomain in complex with Xenopus RSPO2 Fu1-Fu2 (Seleno Met) crystal form II 手法: X-RAY DIFFRACTION / 解像度: 3 Å PDB-4c9r: Xenopus ZNRF3 ectodomain in complex with Xenopus RSPO2 Fu1-Fu2 crystal form I 手法: X-RAY DIFFRACTION / 解像度: 2.1 Å PDB-4c9u: Xenopus ZNRF3 ectodomain in complex with Xenopus RSPO2 Fu1-Fu2 crystal form II 手法: X-RAY DIFFRACTION / 解像度: 3 Å PDB-4c9v: Xenopus RNF43 ectodomain in complex with Xenopus RSPO2 Fu1-Fu2 手法: X-RAY DIFFRACTION / 解像度: 2.7 Å |
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化合物 | |
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由来 | ![](img/tx_fish.gif) danio rerio (ゼブラフィッシュ)![](img/tx_mammal.gif) mus musculus (ハツカネズミ) xenopus (silurana) tropicalis (ネッタイツメガエル)
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キーワード | LIGASE / WNT / RNF43 / LGR4 / LGR5 / LGR6 / RSPO / R-SPONDIN / R-SPO / RSPO1 / RSPO2 / RSPO3 / RSPO4 / RECEPTOR / MEMBRANE / SIGNALLING / SIGNALING PROTEIN / ZNRF3 / LIGASE/SIGNALING PROTEIN / LIGASE-SIGNALING PROTEIN COMPLEX |
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