EMDB/PDB/SASBDBから引用されている文献のデータベース

キーワード
構造解析手法	All X線回折 NMR 電子顕微鏡小角散乱中性子線回折線維回折粉末回折赤外分光 EPR FRET 理論モデルハイブリッド
著者・登録者
ジャーナル
IF	>30 >20 >10 >5 all

タイトル	Ex-527 Inhibits Sirtuins by Exploiting Their Unique Nad+-Dependent Deacetylation Mechanism
ジャーナル・号・ページ	Proc. Natl. Acad. Sci. USA, Vol. 110, Page E2772-, Year 2013
掲載日	2013年6月24日 (構造データの登録日)
著者	Gertz, M. / Fischer, F. / Nguyen, G.T.T. / Lakshminarasimhan, M. / Schutkowski, M. / Weyand, M. / Steegborn, C.
リンク	Proc. Natl. Acad. Sci. USA / PubMed:23840057
手法	X線回折
解像度	1.9 - 3.3 Å
構造データ	PDB-4buz: SIR2 COMPLEX STRUCTURE MIXTURE OF EX-527 INHIBITOR AND REACTION PRODUCTS OR OF REACTION SUBSTRATES P53 PEPTIDE AND NAD 手法: X-RAY DIFFRACTION / 解像度: 1.9 Å PDB-4bv2: CRYSTAL STRUCTURE OF SIR2 IN COMPLEX WITH THE INHIBITOR EX-527, 2'-O-ACETYL-ADP-RIBOSE AND DEACETYLATED P53-PEPTIDE 手法: X-RAY DIFFRACTION / 解像度: 3.3 Å PDB-4bv3: CRYSTAL STRUCTURE OF SIRT3 IN COMPLEX WITH THE INHIBITOR EX-527 AND NAD 手法: X-RAY DIFFRACTION / 解像度: 2.0 Å PDB-4bvb: CRYSTAL STRUCTURE OF HUMAN SIRT3 IN COMPLEX WITH THE INHIBITOR EX-527 AND ADP-RIBOSE 手法: X-RAY DIFFRACTION / 解像度: 2.0 Å PDB-4bve: CRYSTAL STRUCTURE OF HUMAN SIRT3 IN COMPLEX WITH THIOALKYLIMIDATE FORMED FROM THIO-ACETYL-LYSINE ACS2-PEPTIDE 手法: X-RAY DIFFRACTION / 解像度: 2.05 Å PDB-4bvf: CRYSTAL STRUCTURE OF HUMAN SIRT3 IN COMPLEX WITH THIOALKYLIMIDATE FORMED FROM THIO-ACETYL-LYSINE ACS2-PEPTIDE CRYSTALLIZED IN PRESENCE OF THE INHIBITOR EX-527 手法: X-RAY DIFFRACTION / 解像度: 2.7 Å PDB-4bvg: CRYSTAL STRUCTURE OF HUMAN SIRT3 IN COMPLEX WITH NATIVE ALKYLIMIDATE FORMED FROM ACETYL-LYSINE ACS2-PEPTIDE CRYSTALLIZED IN PRESENCE OF THE INHIBITOR EX-527 手法: X-RAY DIFFRACTION / 解像度: 2.5 Å PDB-4bvh: CRYSTAL STRUCTURE OF HUMAN SIRT3 IN COMPLEX WITH THE INHIBITOR EX-527 AND 2'-O-ACETYL-ADP-RIBOSE 手法: X-RAY DIFFRACTION / 解像度: 1.9 Å
化合物	ChemComp-OCZ: (1S)-6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1- carboxamide ChemComp-NAD: NICOTINAMIDE-ADENINE-DINUCLEOTIDE / NADYM ChemComp-OAD: 2'-O-ACETYL ADENOSINE-5-DIPHOSPHORIBOSE ChemComp-ZN: Unknown entry ChemComp-EDO: 1,2-ETHANEDIOL / エチレングリコ-ル ChemComp-HOH: WATER ChemComp-APR: ADENOSINE-5-DIPHOSPHORIBOSE ChemComp-NO3: NITRATE ION ChemComp-GOL: GLYCEROL / グリセロ-ル ChemComp-NA: Unknown entry / ナトリウムカチオン ChemComp-CL: Unknown entry / クロリド ChemComp-AR6: [(2R,3S,4R,5R)-5-(6-AMINOPURIN-9-YL)-3,4-DIHYDROXY-OXOLAN-2-YL]METHYL ChemComp-PEG: DI(HYDROXYETHYL)ETHER / ジエチレングリコ-ル ChemComp-SO4: SULFATE ION / 硫酸ジアニオン ChemComp-XYQ*: (2R,3R,4S,5R)-5-({[(R)-{[(R)-{[(2R,3S,4R,5R)-5-(6-AMINO-9H-PURIN-9-YL)-3,4-DIHYDROXYTETRAHYDROFURAN-2-YL]METHOXY}(HYDROXY)PHOSPHORYL]OXY}(HYDROXY)PHOSPHORYL]OXY}METHYL)-3,4-DIHYDROXYTETRAHYDROFURAN-2-YL ACETATE
由来	thermotoga maritima (バクテリア) homo sapiens (ヒト)
キーワード	HYDROLASE / NAD-DEPENDENT DEACETYLASE / SIRTUIN / INHIBITOR COMPLEX / EX-527 / RUNNING REACTION / ACETYLATED ADP-RIBOSE / HYDROLASE-HYDROLASE / INHIBITOR / ADP-RIBOSE / HYDROLASE/LIGASE / HYDROLASE-LIGASE COMPLEX / THIO-INTERMEDIATE / NATIVE INTERMEDIATE