EMDB/PDB/SASBDBから引用されている文献のデータベース

キーワード
構造解析手法	All X線回折 NMR 電子顕微鏡小角散乱中性子線回折線維回折粉末回折赤外分光 EPR FRET 理論モデルハイブリッド
著者・登録者
ジャーナル
IF	>30 >20 >10 >5 all

タイトル	A Novel Mechanism by Which Small Molecule Inhibitors Induce the DFG Flip in Aurora A.
ジャーナル・号・ページ	Acs Chem. Biol., Vol. 7, Page 698-706, Year 2012
掲載日	2011年11月15日 (構造データの登録日)
著者	Martin, M.P. / Zhu, J.Y. / Lawrence, H.R. / Pireddu, R. / Luo, Y. / Alam, R. / Ozcan, S. / Sebti, S.M. / Lawrence, N.J. / Schonbrunn, E.
リンク	Acs Chem. Biol. / PubMed:22248356
手法	X線回折
解像度	1.9001 - 2.9506 Å
構造データ	PDB-3unj: CDK2 in complex with inhibitor YL1-038-31 手法: X-RAY DIFFRACTION / 解像度: 1.9001 Å PDB-3unk: CDK2 in complex with inhibitor YL5-083 手法: X-RAY DIFFRACTION / 解像度: 2.1 Å PDB-3unz: Aurora A in Complex with RPM1679 手法: X-RAY DIFFRACTION / 解像度: 2.8 Å PDB-3uo4: Aurora A in complex with RPM1680 手法: X-RAY DIFFRACTION / 解像度: 2.45 Å PDB-3uo5: Aurora A in complex with YL1-038-31 手法: X-RAY DIFFRACTION / 解像度: 2.7012 Å PDB-3uo6: Aurora A in complex with YL5-083 手法: X-RAY DIFFRACTION / 解像度: 2.8002 Å PDB-3uod: Aurora A in complex with RPM1693 手法: X-RAY DIFFRACTION / 解像度: 2.5002 Å PDB-3uoh: Aurora A in complex with RPM1722 手法: X-RAY DIFFRACTION / 解像度: 2.8002 Å PDB-3uoj: Aurora A in complex with RPM1715 手法: X-RAY DIFFRACTION / 解像度: 2.9003 Å PDB-3uok: Aurora A in complex with YL5-81-1 手法: X-RAY DIFFRACTION / 解像度: 2.9506 Å PDB-3uol: Aurora A in complex with SO2-162 手法: X-RAY DIFFRACTION / 解像度: 2.4 Å PDB-3up2: Aurora A in complex with RPM1686 手法: X-RAY DIFFRACTION / 解像度: 2.3001 Å
化合物	ChemComp-0BX: 4-{[4-(phenylamino)pyrimidin-2-yl]amino}benzoic acid ChemComp-PO4: PHOSPHATE ION / ホスファ-ト ChemComp-HOH: WATER ChemComp-0BY: 4-({4-[(2-chlorophenyl)amino]pyrimidin-2-yl}amino)benzoic acid ChemComp-0BZ: 4-({4-[(2-fluorophenyl)amino]pyrimidin-2-yl}amino)benzoic acid ChemComp-EDO: 1,2-ETHANEDIOL / エチレングリコ-ル ChemComp-0C0: 4-{[4-(biphenyl-2-ylamino)pyrimidin-2-yl]amino}benzoic acid ChemComp-0C3: 4-[(4-{[2-(trifluoromethyl)phenyl]amino}pyrimidin-2-yl)amino]benzoic acid ChemComp-PEG: DI(HYDROXYETHYL)ETHER / ジエチレングリコ-ル ChemComp-0C4: 4-({4-[(2-bromophenyl)amino]pyrimidin-2-yl}amino)benzoic acid ChemComp-0C5: 4-({4-[(2-cyanophenyl)amino]pyrimidin-2-yl}amino)benzoic acid ChemComp-0C6: 4-({4-[(2-chlorophenyl)amino]-5-fluoropyrimidin-2-yl}amino)benzoic acid ChemComp-0C7: N~4~-(2-chlorophenyl)-N~2~-[4-(1H-tetrazol-5-yl)phenyl]pyrimidine-2,4-diamine ChemComp-0C8: 4-[(4-{[2-(trifluoromethoxy)phenyl]amino}pyrimidin-2-yl)amino]benzoic acid
由来	homo sapiens (ヒト)
キーワード	TRANSFERASE/TRANSFERASE INHIBITOR / Protein kinase / allosteric ligand / ANS / TRANSFERASE-TRANSFERASE INHIBITOR complex / aurora A / inhibitor / DFG-out / DFG-in