タイトル | Antibacterial drug leads targeting isoprenoid biosynthesis. |
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ジャーナル・号・ページ | Proc. Natl. Acad. Sci. USA, Vol. 110, Page 123-128, Year 2013 |
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掲載日 | 2011年6月15日 (構造データの登録日) |
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著者 | Zhu, W. / Zhang, Y. / Sinko, W. / Hensler, M.E. / Olson, J. / Molohon, K.J. / Lindert, S. / Cao, R. / Li, K. / Wang, K. ...Zhu, W. / Zhang, Y. / Sinko, W. / Hensler, M.E. / Olson, J. / Molohon, K.J. / Lindert, S. / Cao, R. / Li, K. / Wang, K. / Wang, Y. / Liu, Y.L. / Sankovsky, A. / de Oliveira, C.A. / Mitchell, D.A. / Nizet, V. / McCammon, J.A. / Oldfield, E. |
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リンク | Proc. Natl. Acad. Sci. USA / PubMed:23248302 |
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手法 | X線回折 |
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解像度 | 1.3 - 2.45 Å |
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構造データ | PDB-3sgt: Crystal Structure of E. coli undecaprenyl pyrophosphate synthase in complex with BPH-1299 手法: X-RAY DIFFRACTION / 解像度: 1.85 Å PDB-3sgv: Crystal Structure of E. coli undecaprenyl pyrophosphate synthase in complex with BPH-1290 手法: X-RAY DIFFRACTION / 解像度: 1.61 Å PDB-3sgx: Crystal Structure of E. coli undecaprenyl pyrophosphate synthase in complex with BPH-1100 手法: X-RAY DIFFRACTION / 解像度: 2.45 Å PDB-3sh0: Crystal Structure of E. coli undecaprenyl pyrophosphate synthase in complex with BPH-1065 手法: X-RAY DIFFRACTION / 解像度: 1.84 Å PDB-4h2j: Structure of E. coli undecaprenyl diphosphate synthase in complex with BPH-1354 手法: X-RAY DIFFRACTION / 解像度: 1.81 Å PDB-4h2m: Structure of E. coli undecaprenyl diphosphate synthase in complex with BPH-1408 手法: X-RAY DIFFRACTION / 解像度: 1.78 Å PDB-4h2o: Structure of E. coli undecaprenyl diphosphate synthase in complex with BPH-1248 手法: X-RAY DIFFRACTION / 解像度: 2.14 Å PDB-4h38: Structure of E. coli undecaprenyl diphosphate synthase in complex with BPH-1297 手法: X-RAY DIFFRACTION / 解像度: 1.95 Å PDB-4h3a: Structure of E. coli undecaprenyl diphosphate synthase in complex with BPH-1330 手法: X-RAY DIFFRACTION / 解像度: 1.98 Å PDB-4h3c: Structure of E. coli undecaprenyl diphosphate synthase in complex with BPH-987 手法: X-RAY DIFFRACTION / 解像度: 1.93 Å PDB-4h8e: Structure of S. aureus undecaprenyl diphosphate synthase in complex with FPP and sulfate 手法: X-RAY DIFFRACTION / 解像度: 1.3 Å |
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化合物 | ChemComp-P09: 2-{[4-(3,4-dimethylphenoxy)phenyl]carbamoyl}benzoic acid
ChemComp-2BJ: 2-{[3-(3,4-dimethylphenoxy)phenyl]carbamoyl}-4-nitrobenzoic acid
ChemComp-0FW: 4-{3-[(biphenyl-4-ylcarbonyl)amino]phenoxy}benzene-1,2-dicarboxylic acid
ChemComp-0YU: N~4~-[4-(4,5-dihydro-1H-imidazol-2-yl)phenyl]-N~1~-[4-(1H-imidazol-2-yl)phenyl]-2-nitrobenzene-1,4-dicarboxamide
ChemComp-0YW: 2-{[3-(decyloxy)benzoyl]amino}-5-nitrobenzoic acid
ChemComp-0YX: (5-bromo-2-{[3-(octyloxy)benzyl]oxy}phenyl)phosphonic acid
ChemComp-0YY: (2Z)-2-hydroxy-4-[4-(octyloxy)phenyl]-4-oxobut-2-enoic acid
ChemComp-0YZ: (2Z)-4-[3-(decyloxy)phenyl]-2-hydroxy-4-oxobut-2-enoic acid
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由来 | - escherichia coli o6 (大腸菌)
- escherichia coli (大腸菌)
- staphylococcus aureus subsp. aureus (黄色ブドウ球菌)
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キーワード | TRANSFERASE/TRANSFERASE INHIBITOR / Alpha/beta / TRANSFERASE-TRANSFERASE INHIBITOR complex / TRANSFERASE / prenyl transferase inhibitor complex / alpha-helix / prenyl transferase / cell wall biosynthesis / farnesyl diphosphate binding / isopentenyl diphosphate binding |
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