タイトル | From crystal packing to molecular recognition: prediction and discovery of a binding site on the surface of polo-like kinase 1 |
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ジャーナル・号・ページ | Angew. Chem. Int. Ed. Engl., Vol. 50, Page 4003-4006, Year 2011 |
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掲載日 | 2010年10月4日 (構造データの登録日) |
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著者 | Sledz, P. / Stubbs, C.J. / Lang, S. / Yang, Y.Q. / McKenzie, G.J. / Venkitaraman, A.R. / Hyvonen, M. / Abell, C. |
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リンク | Angew. Chem. Int. Ed. Engl. / PubMed:21472932 |
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手法 | X線回折 |
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解像度 | 1.4 - 2.38 Å |
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構造データ | PDB-3p2w: Unliganded form of Polo-like kinase I Polo-box domain 手法: X-RAY DIFFRACTION / 解像度: 1.66 Å PDB-3p2z: Polo-like kinase I Polo-box domain in complex with PLHSpTA phosphopeptide from PBIP1 手法: X-RAY DIFFRACTION / 解像度: 1.79 Å PDB-3p34: Polo-like kinase I Polo-box domain in complex with MQSpTPL phosphopeptide 手法: X-RAY DIFFRACTION / 解像度: 1.4 Å PDB-3p35: Polo-like kinase I Polo-box domain in complex with MQSpSPL phosphopeptide 手法: X-RAY DIFFRACTION / 解像度: 2.09 Å PDB-3p36: Polo-like kinase I Polo-box domain in complex with DPPLHSpTA phosphopeptide from PBIP1 手法: X-RAY DIFFRACTION / 解像度: 1.59 Å PDB-3p37: Polo-like kinase I Polo-box domain in complex with FDPPLHSpTA phosphopeptide from PBIP1 手法: X-RAY DIFFRACTION / 解像度: 2.38 Å PDB-3q1i: Polo-like kinase I Polo-box domain in complex with FMPPPMSpSM phosphopeptide from TCERG1 手法: X-RAY DIFFRACTION / 解像度: 1.4 Å |
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化合物 | |
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由来 | homo sapiens (ヒト)
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キーワード | TRANSFERASE / phosphoprotein binding domain / Plk1 / KINASE / PEPTIDE BINDING PROTEIN |
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