EMDB/PDB/SASBDBから引用されている文献のデータベース

キーワード
構造解析手法	All X線回折 NMR 電子顕微鏡小角散乱中性子線回折線維回折粉末回折赤外分光 EPR FRET 理論モデルハイブリッド
著者・登録者
ジャーナル
IF	>30 >20 >10 >5 all

タイトル	Substrate envelope-designed potent HIV-1 protease inhibitors to avoid drug resistance.
ジャーナル・号・ページ	Chem. Biol., Vol. 20, Page 1116-1124, Year 2013
掲載日	2010年8月4日 (構造データの登録日)
著者	Nalam, M.N. / Ali, A. / Reddy, G.S. / Cao, H. / Anjum, S.G. / Altman, M.D. / Yilmaz, N.K. / Tidor, B. / Rana, T.M. / Schiffer, C.A.
リンク	Chem. Biol. / PubMed:24012370
手法	X線回折
解像度	1.45 - 1.95 Å
構造データ	PDB-3o99: Crystal Structure of wild-type HIV-1 Protease in complex with kd13 手法: X-RAY DIFFRACTION / 解像度: 1.95 Å PDB-3o9a: Crystal Structure of wild-type HIV-1 Protease in complex with kd14 手法: X-RAY DIFFRACTION / 解像度: 1.9 Å PDB-3o9b: Crystal Structure of wild-type HIV-1 Protease in Complex with kd25 手法: X-RAY DIFFRACTION / 解像度: 1.5 Å PDB-3o9c: Crystal Structure of wild-type HIV-1 Protease in complex with kd20 手法: X-RAY DIFFRACTION / 解像度: 1.85 Å PDB-3o9d: Crystal Structure of wild-type HIV-1 Protease in complex with kd19 手法: X-RAY DIFFRACTION / 解像度: 1.85 Å PDB-3o9e: Crystal Structure of wild-type HIV-1 Protease in complex with af60 手法: X-RAY DIFFRACTION / 解像度: 1.5 Å PDB-3o9f: Crystal Structure of wild-type HIV-1 Protease in complex with kd27 手法: X-RAY DIFFRACTION / 解像度: 1.7 Å PDB-3o9g: Crystal Structure of wild-type HIV-1 Protease in complex with af53 手法: X-RAY DIFFRACTION / 解像度: 1.65 Å PDB-3o9h: Crystal Structure of wild-type HIV-1 Protease in complex with kd26 手法: X-RAY DIFFRACTION / 解像度: 1.7 Å PDB-3o9i: Crystal Structure of wild-type HIV-1 Protease in complex with af61 手法: X-RAY DIFFRACTION / 解像度: 1.45 Å
化合物	ChemComp-PO4: PHOSPHATE ION / ホスファ-ト ChemComp-K13: (3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-yl [(1S,2R)-3-{[(4-aminophenyl)sulfonyl][(2S)-2-methylbutyl]amino}-1-benzyl-2-hydroxypropyl]carbamate ChemComp-ACT: ACETATE ION / 酢酸イオン ChemComp-HOH: WATER ChemComp-K14: (3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-yl [(1S,2R)-1-benzyl-2-hydroxy-3-{[(4-methoxyphenyl)sulfonyl][(2S)-2-methylbutyl]amino}propyl]carbamate ChemComp-GOL: GLYCEROL / グリセロ-ル ChemComp-K2A: (3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-yl [(1S,2R)-1-benzyl-2-hydroxy-3-({[4-(hydroxymethyl)phenyl]sulfonyl}[(2S)-2-methylbutyl]amino)propyl]carbamate ChemComp-K20: (3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-yl [(1S,2R)-3-{(1,3-benzodioxol-5-ylsulfonyl)[(2S)-2-methylbutyl]amino}-1-benzyl-2-hydroxypropyl]carbamate ChemComp-K19: (3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-yl [(1S,2R)-3-{(1,3-benzothiazol-6-ylsulfonyl)[(2S)-2-methylbutyl]amino}-1-benzyl-2-hydroxypropyl]carbamate ChemComp-A60: (3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-yl [(1S,2R)-3-{[(4-aminophenyl)sulfonyl](2-ethylbutyl)amino}-1-benzyl-2-hydroxypropyl]carbamate ChemComp-K2D: (3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-yl [(1S,2R)-1-benzyl-3-{(2-ethylbutyl)[(4-methoxyphenyl)sulfonyl]amino}-2-hydroxypropyl]carbamate ChemComp-F53: (3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-yl {(1S,2R)-1-benzyl-3-[(2-ethylbutyl){[4-(hydroxymethyl)phenyl]sulfonyl}amino]-2-hydroxypropyl}carbamate ChemComp-K2E: (3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-yl {(1S,2R)-3-[(1,3-benzodioxol-5-ylsulfonyl)(2-ethylbutyl)amino]-1-benzyl-2-hydroxypropyl}carbamate ChemComp-A61: (3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-yl {(1S,2R)-3-[(1,3-benzothiazol-6-ylsulfonyl)(2-ethylbutyl)amino]-1-benzyl-2-hydroxypropyl}carbamate
由来	human immunodeficiency virus 1 (ヒト免疫不全ウイルス)
キーワード	HYDROLASE/HYDROLASE INHIBITOR / HIV-1 protease / drug resistance / drug design / Protease inhibitors / AIDS / Aspartyl protease / HYDROLASE-HYDROLASE INHIBITOR complex