タイトル Critical roles of hydrophobicity and orientation of side chains for inactivation of sarcoplasmic reticulum Ca2+-ATPase with thapsigargin and thapsigargin analogs ジャーナル・号・ページ J. Biol. Chem. , Vol. 285, Page 28883-28892, Year 2010掲載日 2010年6月2日 (構造データの登録日) 著者Winther, A.M.L. / Liu, H. / Sonntag, Y. / Olesen, C. / le Maire, M. / Soehoel, H. / Olsen, C.E. / Christensen, S.B. / Nissen, P. / Moller, J.V. リンク J. Biol. Chem. / PubMed:20551329手法 X線回折 解像度 2.65 - 3.1 Å 構造データ PDB-3nal : 構造ビューア SR Ca(2+)-ATPase in the HnE2 state complexed with the Thapsigargin derivative DTB 手法 : X-RAY DIFFRACTION / 解像度 : 2.65 Å
PDB-3nam : 構造ビューア SR Ca(2+)-ATPase in the HnE2 state complexed with the Thapsigargin derivative dOTg 手法 : X-RAY DIFFRACTION / 解像度 : 3.1 Å
PDB-3nan : 構造ビューア SR Ca(2+)-ATPase in the HnE2 state complexed with a Thapsigargin derivative Boc-(phi)Tg 手法 : X-RAY DIFFRACTION / 解像度 : 3.1 Å
化合物 ChemComp-DBK : 構造ビューア (3S,3aR,4S,6S,6aS,8R,9bS)-6-(acetyloxy)-3,3a-dihydroxy-3,6,9-trimethyl-8-{[(2Z)-2-methylbut-2-enoyl]oxy}-2-oxo-2,3,3a,4,5,6,6a,7,8,9b-decahydroazuleno[4,5-b]furan-4-yl dodecanoate
ChemComp-OTK : 構造ビューア (3S,3aR,4S,6S,6aS,8R,9R,9aR,9bS)-6-(acetyloxy)-4-(butanoyloxy)-3,3a-dihydroxy-3,6,9-trimethyl-2-oxododecahydroazuleno[4,5-b]furan-8-yl (2Z)-2-methylbut-2-enoate
ChemComp-HZ1 : 構造ビューア (3S,3aR,4S,6S,6aR,7S,8S,9R,9aS,9bS)-6-(acetyloxy)-4-{[4-(3-{6-[(tert-butoxycarbonyl)amino]hexyl}-4-hydroxyphenyl)butanoyl]oxy}-3,3a-dihydroxy-3,6,9-trimethyl-8-{[(2Z)-2-methylbut-2-enoyl]oxy}-2-oxododecahydroazuleno[4,5-b]furan-7-yl octanoate
由来 oryctolagus cuniculus (ウサギ) キーワード HYDROLASE / SERCA / P-Type ATPase / Ca2+-ATPase / Thapsigargin / Prostate Cancer / Calcium Transport / Endoplasmic Reticulum / Ion Transport / Sarcoplasmic Reticulum / Transmembrane / Transport