タイトル | Design of phosphodiesterase 4D (PDE4D) allosteric modulators for enhancing cognition with improved safety. |
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ジャーナル・号・ページ | Nat. Biotechnol., Vol. 28, Page 63-70, Year 2010 |
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掲載日 | 2009年2月3日 (構造データの登録日) |
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著者 | Burgin, A.B. / Magnusson, O.T. / Singh, J. / Witte, P. / Staker, B.L. / Bjornsson, J.M. / Thorsteinsdottir, M. / Hrafnsdottir, S. / Hagen, T. / Kiselyov, A.S. ...Burgin, A.B. / Magnusson, O.T. / Singh, J. / Witte, P. / Staker, B.L. / Bjornsson, J.M. / Thorsteinsdottir, M. / Hrafnsdottir, S. / Hagen, T. / Kiselyov, A.S. / Stewart, L.J. / Gurney, M.E. |
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リンク | Nat. Biotechnol. / PubMed:20037581 |
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手法 | X線回折 |
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解像度 | 1.9 - 2.65 Å |
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構造データ | PDB-3g45: Crystal structure of human phosphodiesterase 4b with regulatory domain and d155988 手法: X-RAY DIFFRACTION / 解像度: 2.63 Å PDB-3g4g: Crystal structure of human phosphodiesterase 4d with regulatory domain and d155871 手法: X-RAY DIFFRACTION / 解像度: 2.3 Å PDB-3g4i: Crystal structure of human phosphodiesterase 4d with d155871 手法: X-RAY DIFFRACTION / 解像度: 1.9 Å PDB-3g4k: Crystal structure of human phosphodiesterase 4d with rolipram 手法: X-RAY DIFFRACTION / 解像度: 1.95 Å PDB-3g4l: Crystal structure of human phosphodiesterase 4d with roflumilast 手法: X-RAY DIFFRACTION / 解像度: 2.5 Å PDB-3g58: Crystal structure of human phosphodiesterase 4d with d155988/pmnpq 手法: X-RAY DIFFRACTION / 解像度: 2.05 Å PDB-3iad: Crystal structure of human phosphodiesterase 4D with bound allosteric modulator 手法: X-RAY DIFFRACTION / 解像度: 2.65 Å |
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化合物 | ChemComp-988: 8-(3-nitrophenyl)-6-(pyridin-4-ylmethyl)quinoline
ChemComp-D71: 1-(3-nitrophenyl)-3-(pyridin-4-ylmethyl)pyrido[2,3-d]pyrimidine-2,4(1H,3H)-dione
ChemComp-ROF: 3-(CYCLOPROPYLMETHOXY)-N-(3,5-DICHLOROPYRIDIN-4-YL)-4-(DIFLUOROMETHOXY)BENZAMIDE / ロフルミラスト / 薬剤, 抗炎症剤, 阻害剤*YM / ロフルミラスト
ChemComp-15X: 1-{4-[(2-fluoro-6-methoxy-3'-nitrobiphenyl-3-yl)methyl]phenyl}urea
ChemComp-EPE: 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID / HEPES / pH緩衝剤*YM / HEPES
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由来 | ![](img/tx_human.gif) homo sapiens (ヒト)
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キーワード | HYDROLASE (加水分解酵素) / phosphodiesterase (ホスホジエステラーゼ) / Alternative splicing (選択的スプライシング) / cAMP (CAMP) / Phosphoprotein / Polymorphism / PDE4D / UCR2 / Cytoplasm (細胞質) / Cytoskeleton (細胞骨格) / Membrane (生体膜) / Metal-binding / Allosteric modulatory / inhibitor (酵素阻害剤) |
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