タイトル | Novel adenosine-derived inhibitors of 70 kDa heat shock protein, discovered through structure-based design |
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ジャーナル・号・ページ | J. Med. Chem., Vol. 52, Page 1510-1513, Year 2009 |
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掲載日 | 2009年1月26日 (構造データの登録日) |
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著者 | Williamson, D.S. / Borgognoni, J. / Clay, A. / Daniels, Z. / Dokurno, P. / Drysdale, M.J. / Foloppe, N. / Francis, G.L. / Graham, C.J. / Howes, R. ...Williamson, D.S. / Borgognoni, J. / Clay, A. / Daniels, Z. / Dokurno, P. / Drysdale, M.J. / Foloppe, N. / Francis, G.L. / Graham, C.J. / Howes, R. / Macias, A.T. / Murray, J.B. / Parsons, R. / Shaw, T. / Surgenor, A.E. / Terry, L. / Wang, Y. / Wood, M. / Massey, A.J. |
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リンク | J. Med. Chem. / PubMed:19256508 |
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手法 | X線回折 |
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解像度 | 2 - 2.3 Å |
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構造データ | PDB-3fzf: Crystal Structure of Hsc70/Bag1 in complex with ATP 手法: X-RAY DIFFRACTION / 解像度: 2.2 Å PDB-3fzh: Crystal Structures of Hsc70/Bag1 in Complex with Small Molecule Inhibitors 手法: X-RAY DIFFRACTION / 解像度: 2 Å PDB-3fzk: Crystal Structures of Hsc70/Bag1 in Complex with Small Molecule Inhibitors 手法: X-RAY DIFFRACTION / 解像度: 2.1 Å PDB-3fzl: Crystal Structures of Hsc70/Bag1 in Complex with Small Molecule Inhibitors 手法: X-RAY DIFFRACTION / 解像度: 2.2 Å PDB-3fzm: Crystal Structures of Hsc70/Bag1 in Complex with Small Molecule Inhibitors 手法: X-RAY DIFFRACTION / 解像度: 2.3 Å |
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化合物 | ChemComp-ATP: ADENOSINE-5'-TRIPHOSPHATE / ATP / ATP, エネルギー貯蔵分子*YM / アデノシン三リン酸
ChemComp-3BK: (2R,3R,4S,5R)-2-[6-amino-8-[(3,4-dichlorophenyl)methylamino]purin-9-yl]-5-(hydroxymethyl)oxolane-3,4-diol
ChemComp-3FD: 4-[[(2R,3S,4R,5R)-5-[6-amino-8-[(3,4-dichlorophenyl)methylamino]purin-9-yl]-3,4-dihydroxy-oxolan-2-yl]methoxymethyl]benzonitrile / VER-155008
ChemComp-3GO: 4-[[(2R,3S,4R,5R)-5-[6-amino-8-(quinolin-6-ylmethylamino)purin-9-yl]-3,4-dihydroxy-oxolan-2-yl]methoxymethyl]benzonitri
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由来 | ![](img/tx_human.gif) homo sapiens (ヒト)
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キーワード | CHAPERONE (シャペロン) / HSP70 (Hsp70) / HSC70 (HSPA8) / BAG1 / heat shock / protein folding (フォールディング) / adenosine (アデノシン) / nucleoside (ヌクレオシド) / nucleotide exchange factor / small molecule inhibitor / ATP-binding / nucleotide-binding / stress response (闘争・逃走反応) / apoptosis (アポトーシス) / nucleotide (ヌクレオチド) |
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