EMDB/PDB/SASBDBから引用されている文献のデータベース

キーワード
構造解析手法	All X線回折 NMR 電子顕微鏡小角散乱中性子線回折線維回折粉末回折赤外分光 EPR FRET 理論モデルハイブリッド
著者・登録者
ジャーナル
IF	>30 >20 >10 >5 all

タイトル	Discovery of leukotriene A4 hydrolase inhibitors using metabolomics biased fragment crystallography.
ジャーナル・号・ページ	J. Med. Chem., Vol. 52, Page 4694-4715, Year 2009
掲載日	2009年1月13日 (構造データの登録日)
著者	Davies, D.R. / Mamat, B. / Magnusson, O.T. / Christensen, J. / Haraldsson, M.H. / Mishra, R. / Pease, B. / Hansen, E. / Singh, J. / Zembower, D. ...Davies, D.R. / Mamat, B. / Magnusson, O.T. / Christensen, J. / Haraldsson, M.H. / Mishra, R. / Pease, B. / Hansen, E. / Singh, J. / Zembower, D. / Kim, H. / Kiselyov, A.S. / Burgin, A.B. / Gurney, M.E. / Stewart, L.J.
リンク	J. Med. Chem. / PubMed:19618939
手法	X線回折
解像度	1.58 - 2.6 Å
構造データ	PDB-3fts: Leukotriene A4 hydrolase in complex with resveratrol 手法: X-RAY DIFFRACTION / 解像度: 2.33 Å PDB-3ftu: Leukotriene A4 hydrolase in complex with dihydroresveratrol 手法: X-RAY DIFFRACTION / 解像度: 1.9 Å PDB-3ftv: Leukotriene A4 hydrolase in complex with fragment N-(pyridin-3-ylmethyl)aniline 手法: X-RAY DIFFRACTION / 解像度: 1.7 Å PDB-3ftw: Leukotriene A4 hydrolase in complex with fragments N-(pyridin-3-ylmethyl)aniline and acetate 手法: X-RAY DIFFRACTION / 解像度: 1.85 Å PDB-3ftx: Leukotriene A4 hydrolase in complex with dihydroresveratrol and bestatin 手法: X-RAY DIFFRACTION / 解像度: 1.96 Å PDB-3fty: Leukotriene A4 hydrolase in complex with fragment 3-(benzyloxy)pyridin-2-amine 手法: X-RAY DIFFRACTION / 解像度: 2.15 Å PDB-3fu0: Leukotriene A4 hydrolase in complex with fragment 4-(4-fluorobenzoyl)pyridine 手法: X-RAY DIFFRACTION / 解像度: 1.8 Å PDB-3fu3: Leukotriene A4 hydrolase in complex with fragment 4-(2-amino-1,3-thiazol-4-yl)phenol 手法: X-RAY DIFFRACTION / 解像度: 2.0 Å PDB-3fu5: Leukotriene A4 hydrolase in complex with (5-thiophen-2-ylthiophen-2-yl)methylamine 手法: X-RAY DIFFRACTION / 解像度: 2.3 Å PDB-3fu6: Leukotriene A4 hydrolase in complex with fragment (4-thiophen-2-ylphenyl)methanamine 手法: X-RAY DIFFRACTION / 解像度: 2.05 Å PDB-3fud: Leukotriene A4 hydrolase in complex with N-methyl-1-(2-thiophen-2-ylphenyl)methanamine 手法: X-RAY DIFFRACTION / 解像度: 2.2 Å PDB-3fue: Leukotriene A4 hydrolase in complex with fragment 5-chloroindole and bestatin 手法: X-RAY DIFFRACTION / 解像度: 2.38 Å PDB-3fuf: Leukotriene A4 hydrolase in complex with fragment 5-fluoroindole and bestatin 手法: X-RAY DIFFRACTION / 解像度: 2.6 Å PDB-3fuh: Leukotriene A4 hydrolase in complex with fragment 5-hydroxyindole and bestatin 手法: X-RAY DIFFRACTION / 解像度: 1.8 Å PDB-3fui: Leukotriene A4 hydrolase in complex with N-benzyl-4-[(2R)-pyrrolidin-2-ylmethoxy]aniline 手法: X-RAY DIFFRACTION / 解像度: 2.2 Å PDB-3fuj: Leukotriene A4 hydrolase in complex with 5-[2-(1H-pyrrol-1-yl)ethoxy]-1H-indole 手法: X-RAY DIFFRACTION / 解像度: 1.9 Å PDB-3fuk: Leukotriene A4 hydrolase in complex with 1-[2-(1H-indol-5-yloxy)ethyl]piperidine-4-carboxylic acid 手法: X-RAY DIFFRACTION / 解像度: 1.95 Å PDB-3fum: Leukotriene A4 hydrolase in complex with (R)-pyridin-4-yl[4-(2-pyrrolidin-1-ylethoxy)phenyl]methanol 手法: X-RAY DIFFRACTION / 解像度: 2.15 Å PDB-3fun: Leukotriene A4 hydrolase in complex with {4-[(2R)-pyrrolidin-2-ylmethoxy]phenyl}(4-thiophen-3-ylphenyl)methanone 手法: X-RAY DIFFRACTION / 解像度: 1.58 Å
化合物	ChemComp-ZN: Unknown entry ChemComp-YB: YTTERBIUM (III) ION / イッテルビウム ChemComp-STL: RESVERATROL / レスベラト-ル / レスベラトロール ChemComp-ACT: ACETATE ION / 酢酸イオン / 酢酸塩 ChemComp-IMD: IMIDAZOLE / 1H-イミダゾ-ル-3-カチオン / イミダゾール ChemComp-HOH: WATER / 水 ChemComp-RE2: 5-[2-(4-hydroxyphenyl)ethyl]benzene-1,3-diol / ジヒドロレスベラトロ-ル / Dihydro-resveratrol ChemComp-11X: N-(pyridin-3-ylmethyl)aniline / N-(3-ピリジルメチル)アニリン ChemComp-BES: 2-(3-AMINO-2-HYDROXY-4-PHENYL-BUTYRYLAMINO)-4-METHYL-PENTANOIC ACID / ベスタチン / プロテアーゼ阻害剤YM / ウベニメクス ChemComp-3IP: 3-(BENZYLOXY)PYRIDIN-2-AMINE / 2-アミノ-3-(ベンジルオキシ)ピリジン ChemComp-22F: (4-fluorophenyl)(pyridin-4-yl)methanone / (4-ピリジル)(p-フルオロフェニル)ケトン ChemComp-92G: 4-(2-amino-1,3-thiazol-4-yl)phenol / 4-(2-アミノ-4-チアゾリル)フェノ-ル ChemComp-492: 1-(2,2'-bithiophen-5-yl)methanamine ChemComp-80G: 1-(4-thiophen-2-ylphenyl)methanamine ChemComp-692: N-methyl-1-(2-thiophen-2-ylphenyl)methanamine ChemComp-11S: 5-chloro-1H-indole / 5-クロロ-1H-インド-ル ChemComp-14O: 5-fluoro-1H-indole / 5-フルオロ-1H-インド-ル ChemComp-5H1: 1H-indol-5-ol / 5-ヒドロキシインド-ル ChemComp-812: N-benzyl-4-[(2R)-pyrrolidin-2-ylmethoxy]aniline ChemComp-00G: 5-[2-(1H-pyrrol-1-yl)ethoxy]-1H-indole ChemComp-58Z: 1-[2-(1H-indol-5-yloxy)ethyl]piperidine-4-carboxylic acid ChemComp-80A: (R)-pyridin-4-yl[4-(2-pyrrolidin-1-ylethoxy)phenyl]methanol ChemComp-798*: {4-[(2R)-pyrrolidin-2-ylmethoxy]phenyl}(4-thiophen-3-ylphenyl)methanone
由来	homo sapiens (ヒト)
キーワード	HYDROLASE (加水分解酵素) / Leukotriene A4 Hydrolase (ロイコトリエンA4ヒドロラーゼ) / LTA4H / Fragment crystallography / Fragments of Life / FOL / Resveratrol (レスベラトロール) / Alternative splicing (選択的スプライシング) / Cytoplasm (細胞質) / Leukotriene biosynthesis / Metal-binding / Metalloprotease (金属プロテアーゼ) / Multifunctional enzyme / Polymorphism / Protease (プロテアーゼ) / Zinc (亜鉛)