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-Structure paper
タイトル | Discovery of 5-[[4-[(2,3-dimethyl-2H-indazol-6-yl)methylamino]-2-pyrimidinyl]amino]-2-methyl-benzenesulfonamide (Pazopanib), a novel and potent vascular endothelial growth factor receptor inhibitor. |
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ジャーナル・号・ページ | J. Med. Chem., Vol. 51, Page 4632-4640, Year 2008 |
掲載日 | 2008年3月12日 (構造データの登録日) |
![]() | Harris, P.A. / Boloor, A. / Cheung, M. / Kumar, R. / Crosby, R.M. / Davis-Ward, R.G. / Epperly, A.H. / Hinkle, K.W. / Hunter, R.N. / Johnson, J.H. ...Harris, P.A. / Boloor, A. / Cheung, M. / Kumar, R. / Crosby, R.M. / Davis-Ward, R.G. / Epperly, A.H. / Hinkle, K.W. / Hunter, R.N. / Johnson, J.H. / Knick, V.B. / Laudeman, C.P. / Luttrell, D.K. / Mook, R.A. / Nolte, R.T. / Rudolph, S.K. / Szewczyk, J.R. / Truesdale, A.T. / Veal, J.M. / Wang, L. / Stafford, J.A. |
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手法 | X線回折 |
解像度 | 2.15 - 2.25 Å |
構造データ | ![]() PDB-3cjf: ![]() PDB-3cjg: |
化合物 | ![]() ChemComp-SO4: ![]() ChemComp-SAV: ![]() ChemComp-HOH: ![]() ChemComp-KIM: |
由来 |
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![]() | TRANSFERASE / Vascular endothelial growth factor receptor 2. vegfr-2 / kinase insert domain receptor / protein-tyrosine kinase receptor flk-1 / Angiogenesis / ATP-binding / Developmental protein / Differentiation / Glycoprotein / Host-virus interaction / Immunoglobulin domain / Membrane / Nucleotide-binding / Phosphoprotein / Transmembrane / Tyrosine-protein kinase |