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TitleDiscovery of 5-[[4-[(2,3-dimethyl-2H-indazol-6-yl)methylamino]-2-pyrimidinyl]amino]-2-methyl-benzenesulfonamide (Pazopanib), a novel and potent vascular endothelial growth factor receptor inhibitor.
Journal, issue, pagesJ. Med. Chem., Vol. 51, Page 4632-4640, Year 2008
Publish dateMar 12, 2008 (structure data deposition date)
AuthorsHarris, P.A. / Boloor, A. / Cheung, M. / Kumar, R. / Crosby, R.M. / Davis-Ward, R.G. / Epperly, A.H. / Hinkle, K.W. / Hunter, R.N. / Johnson, J.H. ...Harris, P.A. / Boloor, A. / Cheung, M. / Kumar, R. / Crosby, R.M. / Davis-Ward, R.G. / Epperly, A.H. / Hinkle, K.W. / Hunter, R.N. / Johnson, J.H. / Knick, V.B. / Laudeman, C.P. / Luttrell, D.K. / Mook, R.A. / Nolte, R.T. / Rudolph, S.K. / Szewczyk, J.R. / Truesdale, A.T. / Veal, J.M. / Wang, L. / Stafford, J.A.
External linksJ. Med. Chem. / PubMed:18620382
MethodsX-ray diffraction
Resolution2.15 - 2.25 Å
Structure data

PDB-3cjf:
Crystal structure of VEGFR2 in complex with a 3,4,5-trimethoxy aniline containing pyrimidine
Method: X-RAY DIFFRACTION / Resolution: 2.15 Å

PDB-3cjg:
Crystal structure of VEGFR2 in complex with a 3,4,5-trimethoxy aniline containing pyrimidine
Method: X-RAY DIFFRACTION / Resolution: 2.25 Å

Chemicals

ChemComp-SO4:
SULFATE ION

ChemComp-SAV:
N~4~-(3-methyl-1H-indazol-6-yl)-N~2~-(3,4,5-trimethoxyphenyl)pyrimidine-2,4-diamine

ChemComp-HOH:
WATER

ChemComp-KIM:
N~4~-methyl-N~4~-(3-methyl-1H-indazol-6-yl)-N~2~-(3,4,5-trimethoxyphenyl)pyrimidine-2,4-diamine

Source
  • homo sapiens (human)
KeywordsTRANSFERASE / Vascular endothelial growth factor receptor 2. vegfr-2 / kinase insert domain receptor / protein-tyrosine kinase receptor flk-1 / Angiogenesis / ATP-binding / Developmental protein / Differentiation / Glycoprotein / Host-virus interaction / Immunoglobulin domain / Membrane / Nucleotide-binding / Phosphoprotein / Transmembrane / Tyrosine-protein kinase

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