タイトル | Structural basis of alpha-fucosidase inhibition by iminocyclitols with K(i) values in the micro- to picomolar range. |
---|
ジャーナル・号・ページ | Angew. Chem. Int. Ed. Engl., Vol. 49, Page 337-340, Year 2010 |
---|
掲載日 | 2008年12月19日 (構造データの登録日) |
---|
著者 | Wu, H.J. / Ho, C.W. / Ko, T.P. / Popat, S.D. / Lin, C.H. / Wang, A.H. |
---|
リンク | Angew. Chem. Int. Ed. Engl. / PubMed:19967696 |
---|
手法 | X線回折 |
---|
解像度 | 2.15 - 2.65 Å |
---|
構造データ | PDB-2zwz: alpha-L-fucosidase complexed with inhibitor, Core1 手法: X-RAY DIFFRACTION / 解像度: 2.36 Å PDB-2zx5: alpha-L-fucosidase complexed with inhibitor, F10 手法: X-RAY DIFFRACTION / 解像度: 2.65 Å PDB-2zx6: alpha-L-fucosidase complexed with inhibitor, F10-1C 手法: X-RAY DIFFRACTION / 解像度: 2.42 Å PDB-2zx7: alpha-L-fucosidase complexed with inhibitor, F10-2C 手法: X-RAY DIFFRACTION / 解像度: 2.48 Å PDB-2zx8: alpha-L-fucosidase complexed with inhibitor, F10-2C-O 手法: X-RAY DIFFRACTION / 解像度: 2.33 Å PDB-2zx9: alpha-L-fucosidase complexed with inhibitor, B4 手法: X-RAY DIFFRACTION / 解像度: 2.62 Å PDB-2zxa: alpha-L-fucosidase complexed with inhibitor, FNJ-acetyl 手法: X-RAY DIFFRACTION / 解像度: 2.57 Å PDB-2zxb: alpha-L-fucosidase complexed with inhibitor, ph-6FNJ 手法: X-RAY DIFFRACTION / 解像度: 2.61 Å PDB-2zxd: alpha-L-fucosidase complexed with inhibitor, iso-6FNJ 手法: X-RAY DIFFRACTION / 解像度: 2.15 Å |
---|
化合物 | ChemComp-ZX6: 2-(1H-indol-3-yl)-N-{[(2R,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methylpiperidin-2-yl]methyl}acetamide
ChemComp-ZX7: N-{[(2R,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methylpiperidin-2-yl]methyl}-1H-indole-2-carboxamide
ChemComp-ZX8: N-{[(2R,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methylpiperidin-2-yl]methyl}-1-benzofuran-2-carboxamide
ChemComp-ZX9: (2S)-2-cyclopentyl-2-phenyl-N-{[(2R,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methylpiperidin-2-yl]methyl}ethanamide
ChemComp-ZXB: (2S,3R,4S,5R)-2-benzylpiperidine-3,4,5-triol
|
---|
由来 | ![](img/tx_bacteria.gif) thermotoga maritima (バクテリア)
|
---|
キーワード | HYDROLASE / Tim Barrel |
---|