タイトル | Structural Basis of Inhibition Specificities of 3C and 3C-like Proteases by Zinc-coordinating and Peptidomimetic Compounds |
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ジャーナル・号・ページ | J. Biol. Chem., Vol. 284, Page 7646-7655, Year 2009 |
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掲載日 | 2008年10月10日 (構造データの登録日) |
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著者 | Lee, C.C. / Kuo, C.J. / Ko, T.P. / Hsu, M.F. / Tsui, Y.C. / Chang, S.C. / Yang, S. / Chen, S.J. / Chen, H.C. / Hsu, M.C. ...Lee, C.C. / Kuo, C.J. / Ko, T.P. / Hsu, M.F. / Tsui, Y.C. / Chang, S.C. / Yang, S. / Chen, S.J. / Chen, H.C. / Hsu, M.C. / Shih, S.R. / Liang, P.H. / Wang, A.H.-J. |
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リンク | J. Biol. Chem. / PubMed:19144641 |
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手法 | X線回折 |
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解像度 | 1.38 - 2 Å |
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構造データ | PDB-2ztx: Complex structure of CVB3 3C protease with EPDTC 手法: X-RAY DIFFRACTION / 解像度: 1.72 Å PDB-2zty: crystal structure of 3C protease from CVB3 in space group C2 手法: X-RAY DIFFRACTION / 解像度: 1.72 Å PDB-2ztz: crystal structure of 3C protease from CVB3 in space group P21 手法: X-RAY DIFFRACTION / 解像度: 2.0 Å PDB-2zu1: crystal structure of CVB3 3C protease mutant C147A 手法: X-RAY DIFFRACTION / 解像度: 1.38 Å PDB-2zu2: complex structure of CoV 229E 3CL protease with EPDTC 手法: X-RAY DIFFRACTION / 解像度: 1.8 Å PDB-2zu3: Complex structure of CVB3 3C protease with TG-0204998 手法: X-RAY DIFFRACTION / 解像度: 1.75 Å PDB-2zu4: Complex structure of SARS-CoV 3CL protease with TG-0204998 手法: X-RAY DIFFRACTION / 解像度: 1.93 Å PDB-2zu5: complex structure of SARS-CoV 3CL protease with TG-0205486 手法: X-RAY DIFFRACTION / 解像度: 1.65 Å |
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化合物 | ChemComp-ZU3: N-[(benzyloxy)carbonyl]-3-[(2,2-dimethylpropanoyl)amino]-L-alanyl-N-[(1R)-4-oxo-1-{[(3S)-2-oxopyrrolidin-3-yl]methyl}pentyl]-L-leucinamide
ChemComp-ZU5: N-[(benzyloxy)carbonyl]-O-tert-butyl-L-threonyl-N-[(1R)-4-cyclopropyl-4-oxo-1-{[(3S)-2-oxopyrrolidin-3-yl]methyl}butyl]-L-leucinamide
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由来 | ![](img/tx_virus.gif) human coxsackievirus b3 (コクサッキーウイルス) human coronavirus (ウイルス)![](img/tx_virus.gif) human coxsackievirus (コクサッキーウイルス) sars coronavirus (SARS コロナウイルス)
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キーワード | HYDROLASE/HYDROLASE INHIBITOR / protease-inhibitor complex / Hydrolase / Protease / Thiol protease / HYDROLASE-HYDROLASE INHIBITOR complex / Metal-binding |
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