タイトル | Structure-Guided Design of Cell Wall Biosynthesis Inhibitors that Overcome Beta-Lactam Resistance in Staphylococcus Aureus (Mrsa). |
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ジャーナル・号・ページ | Acs Chem. Biol., Vol. 6, Page 943-, Year 2011 |
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掲載日 | 2010年12月15日 (構造データの登録日) |
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著者 | Contreras-Martel, C. / Amoroso, A. / Woon, E.C. / Zervosen, A. / Inglis, S. / Martins, A. / Verlaine, O. / Rydzik, A. / Job, V. / Luxen, A. ...Contreras-Martel, C. / Amoroso, A. / Woon, E.C. / Zervosen, A. / Inglis, S. / Martins, A. / Verlaine, O. / Rydzik, A. / Job, V. / Luxen, A. / Joris, B. / Schofield, C.J. / Dessen, A. |
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リンク | Acs Chem. Biol. / PubMed:21732689 |
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手法 | X線回折 |
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解像度 | 1.62 - 2.15 Å |
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構造データ | PDB-2y2g: PENICILLIN-BINDING PROTEIN 1B (PBP-1B) IN COMPLEX WITH AN ALKYL BORONATE (A01) 手法: X-RAY DIFFRACTION / 解像度: 2.05 Å PDB-2y2h: PENICILLIN-BINDING PROTEIN 1B (PBP-1B) IN COMPLEX WITH AN ALKYL BORONATE (ZA2) 手法: X-RAY DIFFRACTION / 解像度: 1.96 Å PDB-2y2i: PENICILLIN-BINDING PROTEIN 1B (PBP-1B) IN COMPLEX WITH AN ALKYL BORONATE (ZA3) 手法: X-RAY DIFFRACTION / 解像度: 1.78 Å PDB-2y2j: PENICILLIN-BINDING PROTEIN 1B (PBP-1B) IN COMPLEX WITH AN ALKYL BORONATE (ZA4) 手法: X-RAY DIFFRACTION / 解像度: 2.06 Å PDB-2y2k: PENICILLIN-BINDING PROTEIN 1B (PBP-1B) IN COMPLEX WITH AN ALKYL BORONATE (ZA5) 手法: X-RAY DIFFRACTION / 解像度: 2.09 Å PDB-2y2l: PENICILLIN-BINDING PROTEIN 1B (PBP-1B) IN COMPLEX WITH AN ALKYL BORONATE (E06) 手法: X-RAY DIFFRACTION / 解像度: 2.07 Å PDB-2y2m: PENICILLIN-BINDING PROTEIN 1B (PBP-1B) IN COMPLEX WITH AN ALKYL BORONATE (E08) 手法: X-RAY DIFFRACTION / 解像度: 1.62 Å PDB-2y2n: PENICILLIN-BINDING PROTEIN 1B (PBP-1B) IN COMPLEX WITH AN ALKYL BORONATE (E07) 手法: X-RAY DIFFRACTION / 解像度: 2.07 Å PDB-2y2o: PENICILLIN-BINDING PROTEIN 1B (PBP-1B) IN COMPLEX WITH AN ALKYL BORONATE (EO9) 手法: X-RAY DIFFRACTION / 解像度: 1.88 Å PDB-2y2p: Penicillin-binding protein 1b (pbp-1b) in complex with an alkyl boronate (z10) 手法: X-RAY DIFFRACTION / 解像度: 1.62 Å PDB-2y2q: PENICILLIN-BINDING PROTEIN 1B (PBP-1B) IN COMPLEX WITH AN ALKYL BORONATE (Z06) 手法: X-RAY DIFFRACTION / 解像度: 2.15 Å |
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化合物 | ChemComp-A01: [(2,6-DIMETHOXYPHENYL)CARBONYLAMINO]METHYL-TRIHYDROXY-BORON
ChemComp-ZA2: [(2-CHLOROPHENYL)CARBONYLAMINO]METHYL-TRIHYDROXY-BORON
ChemComp-ZA3: TRIHYDROXY-[[(2-NITROPHENYL)CARBONYLAMINO]METHYL]BORON
ChemComp-ZA4: [(2-FLUOROPHENYL)CARBONYLAMINO]METHYL-TRIHYDROXY-BORON
ChemComp-ZA5: [(2,6-DIFLUOROPHENYL)CARBONYLAMINO]METHYL-TRIHYDROXY-BORON
ChemComp-E06: [(1R)-1-[(2,6-difluorophenyl)carbonylamino]ethyl]-trihydroxy-boron
ChemComp-E08: TRIHYDROXY-[(1S)-1-[(2-PROPAN-2-YLPHENYL)CARBONYLAMINO]ETHYL]BORON
ChemComp-E07: TRIHYDROXY-[(1S)-1-[[2-(PHENYLMETHYL)PHENYL]CARBONYLAMINO]ETHYL]BORON
ChemComp-EO9: [(1S)-1-[(2,6-difluorophenyl)carbonylamino]ethyl]-trihydroxy-boron
ChemComp-Z10: [(1S)-1-[(2-fluoro-6-phenyl-phenyl)carbonylamino]ethyl]-trihydroxy-boron
ChemComp-Z06: (3-acetamido-5-carboxy-phenyl)-trihydroxy-boron
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由来 | ![](img/tx_bacteria.gif) streptococcus pneumoniae (肺炎レンサ球菌)
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キーワード | TRANSFERASE / INFECTION / CELL WALL / PEPTIDOGLYCAN / INHIBITOR |
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