タイトル | Structure, Function, and Inhibition along the Reaction Coordinate of CTX-M beta-Lactamases. |
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ジャーナル・号・ページ | J. Am. Chem. Soc., Vol. 127, Page 5423-5434, Year 2005 |
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掲載日 | 2005年1月19日 (構造データの登録日) |
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著者 | Chen, Y. / Shoichet, B. / Bonnet, R. |
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リンク | J. Am. Chem. Soc. / PubMed:15826180 |
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手法 | X線回折 |
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解像度 | 1.12 - 1.7 Å |
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構造データ | PDB-1yly: X-ray crystallographic structure of CTX-M-9 beta-lactamase complexed with ceftazidime-like boronic acid 手法: X-RAY DIFFRACTION / 解像度: 1.25 Å PDB-1ylz: X-ray crystallographic structure of CTX-M-14 beta-lactamase complexed with ceftazidime-like boronic acid 手法: X-RAY DIFFRACTION / 解像度: 1.35 Å PDB-1ym1: X-ray crystallographic structure of CTX-M-9 beta-lactamase complexed with a boronic acid inhibitor (SM2) 手法: X-RAY DIFFRACTION / 解像度: 1.12 Å PDB-1yms: X-ray crystallographic structure of CTX-M-9 beta-lactamase complexed with nafcinin-like boronic acid inhibitor 手法: X-RAY DIFFRACTION / 解像度: 1.6 Å PDB-1ymx: X-ray crystallographic structure of CTX-M-9 beta-lactamase covalently linked to cefoxitin 手法: X-RAY DIFFRACTION / 解像度: 1.7 Å |
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化合物 | ChemComp-1QL: (2R)-5-[(carbamoyloxy)methyl]-2-{(1S)-1-methoxy-2-oxo-1-[(thiophen-2-ylacetyl)amino]ethyl}-3,6-dihydro-2H-1,3-thiazine-4-carboxylic acid / 抗生剤*YM
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由来 | - escherichia coli (大腸菌)
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キーワード | HYDROLASE / CTX-M / beta-lactamase / transition state / ceftazidime / boronic acid / deacylation / acylation / acyl-enzyme complex / cefoxitin |
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