Probing the influence of stereoelectronic effects on the biophysical properties of oligonucleotides: comprehensive analysis of the RNA affinity, nuclease resistance, and crystal structure of ten 2'-O-ribonucleic acid modifications.
PDB-1wv5: X-ray structure of the A-decamer GCGTATACGC with a single 2'-o-butyl thymine in place of T6, Mg-form 手法: X-RAY DIFFRACTION / 解像度: 2.3 Å
PDB-1wv6: X-ray structure of the A-decamer GCGTATACGC with a single 2'-O-butyl thymine in place of T6, Sr-form 手法: X-RAY DIFFRACTION / 解像度: 2.55 Å
PDB-1y7f: Crystal structure of the A-DNA GCGTAT*CGC with a 2'-O-[2-[hydroxy(methyleneamino)oxy]ethyl] Thymidine (T*) 手法: X-RAY DIFFRACTION / 解像度: 1.6 Å
PDB-1y84: Crystal structure of the A-DNA GCGTAT*CGC with a 2'-O-[2-(imidazolyl)ethyl] Thymidine (T*) 手法: X-RAY DIFFRACTION / 解像度: 1.6 Å
PDB-1y86: Crystal structure of the A-DNA GCGTAT*CGC with a 2'-O-[2-(fluoro)ethyl] Thymidine (T*) 手法: X-RAY DIFFRACTION / 解像度: 1.7 Å
PDB-1y8l: Crystal structure of the A-DNA GCGTAT*CGC with a 2'-O-[2-(trifluoro)ethyl] Thymidine (T*) 手法: X-RAY DIFFRACTION / 解像度: 1.5 Å
PDB-1y8v: Crystal structure of the A-DNA GCGTAT*CGC with a 2'-O-propyl Thymidine (T*) 手法: X-RAY DIFFRACTION / 解像度: 1.5 Å
PDB-1y9f: Crystal structure of the A-DNA GCGTAT*CGC with a 2'-O-allyl Thymidine (T*) 手法: X-RAY DIFFRACTION / 解像度: 1.6 Å
PDB-1y9s: Crystal structure of the A-DNA GCGTAT*CGC with a 2'-O-propargyl Thymidine (T*) 手法: X-RAY DIFFRACTION / 解像度: 1.55 Å
PDB-1yb9: Crystal structure of the A-DNA GCGTAT*CGC with a 2'-O-[2-(N,N-dimethylaminooxy)ethyl] Thymidine (T*) 手法: X-RAY DIFFRACTION / 解像度: 1.65 Å
PDB-1ybc: Crystal structure of the A-DNA GCGTAT*CGC with a 2'-O-[2-(benzyloxy)ethyl] Thymidine (T*) 手法: X-RAY DIFFRACTION / 解像度: 1.8 Å