EMDB/PDB/SASBDBから引用されている文献のデータベース

キーワード
構造解析手法	All X線回折 NMR 電子顕微鏡小角散乱中性子線回折線維回折粉末回折赤外分光 EPR FRET 理論モデルハイブリッド
著者・登録者
ジャーナル
IF	>30 >20 >10 >5 all

タイトル	Design and crystal structures of protein kinase B-selective inhibitors in complex with protein kinase A and mutants
ジャーナル・号・ページ	J. Med. Chem., Vol. 48, Page 163-170, Year 2005
掲載日	2004年9月17日 (構造データの登録日)
著者	Breitenlechner, C.B. / Friebe, W.-G. / Brunet, E. / Werner, G. / Graul, K. / Thomas, U. / Kuenkele, K.-P. / Schaefer, W. / Gassel, M. / Bossemeyer, D. ...Breitenlechner, C.B. / Friebe, W.-G. / Brunet, E. / Werner, G. / Graul, K. / Thomas, U. / Kuenkele, K.-P. / Schaefer, W. / Gassel, M. / Bossemeyer, D. / Huber, R. / Engh, R.A. / Masjost, B.
リンク	J. Med. Chem. / PubMed:15634010
手法	X線回折
解像度	1.6 - 2.47 Å
構造データ	PDB-1xh4: Crystal Structures of Protein Kinase B Selective Inhibitors in Complex with Protein Kinase A and Mutants 手法: X-RAY DIFFRACTION / 解像度: 2.45 Å PDB-1xh5: Crystal Structures of Protein Kinase B Selective Inhibitors in Complex with Protein Kinase A and Mutants 手法: X-RAY DIFFRACTION / 解像度: 2.05 Å PDB-1xh6: Crystal Structures of Protein Kinase B Selective Inhibitors in Complex with Protein Kinase A and Mutants 手法: X-RAY DIFFRACTION / 解像度: 1.9 Å PDB-1xh7: Crystal Structures of Protein Kinase B Selective Inhibitors in Complex with Protein Kinase A and Mutants 手法: X-RAY DIFFRACTION / 解像度: 2.47 Å PDB-1xh8: Crystal Structures of Protein Kinase B Selective Inhibitors in Complex with Protein Kinase A and Mutants 手法: X-RAY DIFFRACTION / 解像度: 1.6 Å PDB-1xh9: Crystal Structures of Protein Kinase B Selective Inhibitors in Complex with Protein Kinase A and Mutants 手法: X-RAY DIFFRACTION / 解像度: 1.64 Å PDB-1xha: Crystal Structures of Protein Kinase B Selective Inhibitors in Complex with Protein Kinase A and Mutants 手法: X-RAY DIFFRACTION / 解像度: 2.46 Å
化合物	ChemComp-R69: N-[4-({4-[5-(DIMETHYLAMINO)-2-HYDROXYBENZOYL]BENZOYL}AMINO)AZEPAN-3-YL]ISONICOTINAMIDE ChemComp-HOH: WATER ChemComp-R68: N-{4-[(4-{3-[(2R)-3,3-DIMETHYLPIPERIDIN-2-YL]-2-FLUORO-6-HYDROXYBENZOYL}BENZOYL)AMINO]AZEPAN-3-YL}ISONICOTINAMIDE ChemComp-BU3: (R,R)-2,3-BUTANEDIOL / (2R,3R)-2,3-ブタンジオ-ル ChemComp-R94: N-(4-{[4-(2-HYDROXY-5-PIPERIDIN-1-YLBENZOYL)BENZOYL]AMINO}AZEPAN-3-YL)ISONICOTINAMIDE ChemComp-R96: N-[4-({4-[5-(3,3-DIMETHYLPIPERIDIN-1-YL)-2-HYDROXYBENZOYL]BENZOYL}AMINO)AZEPAN-3-YL]ISONICOTINAMIDE ChemComp-R55: N-[4-({4-[5-(4,4-DIMETHYLPIPERIDIN-1-YL)-2-HYDROXYBENZOYL]BENZOYL}AMINO)AZEPAN-3-YL]ISONICOTINAMIDE
由来	bos taurus (ウシ) synthetic construct (人工物)
キーワード	TRANSFERASE/TRANSFERASE INHIBITOR / PKA / kinase-inhibitor-complex / serine/threonine-protein kinase / balanol derivative / TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX