タイトル | Interactions of Ly333531 and Other Bisindolyl Maleimide Inhibitors with Pdk1 |
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ジャーナル・号・ページ | Structure, Vol. 12, Page 215-, Year 2004 |
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掲載日 | 2003年12月15日 (構造データの登録日) |
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著者 | Komander, D. / Kular, G.S. / Schuttelkopf, A.W. / Deak, M. / Prakash, K.R. / Bain, J. / Elliot, M. / Garrido-Franco, M. / Kozikowski, A.P. / Alessi, D.R. / Van Aalten, D.M.F. |
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リンク | Structure / PubMed:14962382 |
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手法 | X線回折 |
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解像度 | 1.7 - 2.81 Å |
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構造データ | PDB-1uu3: Structure of human PDK1 kinase domain in complex with LY333531 手法: X-RAY DIFFRACTION / 解像度: 1.7 Å PDB-1uu7: Structure of human PDK1 kinase domain in complex with BIM-2 手法: X-RAY DIFFRACTION / 解像度: 1.9 Å PDB-1uu8: Structure of human PDK1 kinase domain in complex with BIM-1 手法: X-RAY DIFFRACTION / 解像度: 2.5 Å PDB-1uu9: Structure of human PDK1 kinase domain in complex with BIM-3 手法: X-RAY DIFFRACTION / 解像度: 1.95 Å PDB-1uvr: Structure of human PDK1 kinase domain in complex with BIM-8 手法: X-RAY DIFFRACTION / 解像度: 2.81 Å |
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化合物 | ChemComp-LY4: (9R)-9-[(DIMETHYLAMINO)METHYL]-6,7,10,11-TETRAHYDRO-9H,18H-5,21:12,17-DIMETHENODIBENZO[E,K]PYRROLO[3,4-H][1,4,13]OXADIA / LY-333531
ChemComp-BI2: 3-(1H-INDOL-3-YL)-4-(1-{2-[(2S)-1-METHYLPYRROLIDINYL]ETHYL}-1H-INDOL-3-YL)-1H-PYRROLE-2,5-DIONE
ChemComp-BI1: 3-{1-[3-(DIMETHYLAMINO)PROPYL]-1H-INDOL-3-YL}-4-(1H-INDOL-3-YL)-1H-PYRROLE-2,5-DIONE / GF-109203X
ChemComp-BI8: 3-[1-(3-AMINOPROPYL)-1H-INDOL-3-YL]-4-(1-METHYL-1H-INDOL-3-YL)-1H-PYRROLE-2,5-DIONE / Ro-31-7549
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由来 | homo sapiens (ヒト)![](img/tx_arthropod.gif) spodoptera frugiperda (ツマジロクサヨトウ)
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キーワード | TRANSFERASE / PROTEIN KINASE / PKB / PDK1 / INHIBITOR / LY333531 / DIABETES / CANCER / SERINE/THREONINE-PROTEIN KINASE / BISINDOLYL MALEIMIDE / BIM-1 / BIM-8 |
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