タイトル | Crystal structures of HIV-1 reverse transcriptases mutated at codons 100, 106 and 108 and mechanisms of resistance to non-nucleoside inhibitors |
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ジャーナル・号・ページ | J. Mol. Biol., Vol. 336, Page 569-578, Year 2004 |
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掲載日 | 2004年1月7日 (構造データの登録日) |
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著者 | Ren, J. / Nichols, C.E. / Chamberlain, P.P. / Weaver, K.L. / Short, S.A. / Stammers, D.K. |
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リンク | J. Mol. Biol. / PubMed:15095972 |
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手法 | X線回折 |
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解像度 | 2.4 - 3 Å |
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構造データ | PDB-1s1t: Crystal structure of L100I mutant HIV-1 reverse transcriptase in complex with UC-781 手法: X-RAY DIFFRACTION / 解像度: 2.4 Å PDB-1s1u: Crystal structure of L100I mutant HIV-1 reverse transcriptase in complex with nevirapine 手法: X-RAY DIFFRACTION / 解像度: 3 Å PDB-1s1v: Crystal structure of L100I mutant HIV-1 reverse transcriptase in complex with TNK-651 手法: X-RAY DIFFRACTION / 解像度: 2.6 Å PDB-1s1w: Crystal structure of V106A mutant HIV-1 reverse transcriptase in complex with UC-781 手法: X-RAY DIFFRACTION / 解像度: 2.7 Å PDB-1s1x: Crystal structure of V108I mutant HIV-1 reverse transcriptase in complex with nevirapine 手法: X-RAY DIFFRACTION / 解像度: 2.8 Å |
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化合物 | ChemComp-UC1: 2-METHYL-FURAN-3-CARBOTHIOIC ACID [4-CHLORO-3-(3-METHYL-BUT-2-ENYLOXY)-PHENYL]-AMIDE / UC-781
ChemComp-NVP: 11-CYCLOPROPYL-5,11-DIHYDRO-4-METHYL-6H-DIPYRIDO[3,2-B:2',3'-E][1,4]DIAZEPIN-6-ONE / ネビラピン / 薬剤, 抗レトロウイルス剤*YM
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由来 | - human immunodeficiency virus 1 (ヒト免疫不全ウイルス)
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キーワード | TRANSFERASE / HIV-1 REVERSE TRANSCRIPTASE / AIDS / NNRTI / UC-781 / DRUG RESISTANCE MUTATIONS / NEVIRAPINE / TNK-651 |
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