EMDB/PDB/SASBDBから引用されている文献のデータベース

キーワード
構造解析手法	All X線回折 NMR 電子顕微鏡小角散乱中性子線回折線維回折粉末回折赤外分光 EPR FRET 理論モデルハイブリッド
著者・登録者
ジャーナル
IF	>30 >20 >10 >5 all

タイトル	Untangling desmosomal knots with electron tomography.
ジャーナル・号・ページ	Science, Vol. 302, Issue 5642, Page 109-113, Year 2003
掲載日	2003年10月3日
著者	Wanzhong He / Pamela Cowin / David L Stokes /
PubMed 要旨	Cell adhesion by adherens junctions and desmosomes relies on interactions between cadherin molecules. However, the molecular interfaces that define molecular specificity and that mediate adhesion ...Cell adhesion by adherens junctions and desmosomes relies on interactions between cadherin molecules. However, the molecular interfaces that define molecular specificity and that mediate adhesion remain controversial. We used electron tomography of plastic sections from neonatal mouse skin to visualize the organization of desmosomes in situ. The resulting three-dimensional maps reveal individual cadherin molecules forming discrete groups and interacting through their tips. Fitting of an x-ray crystal structure for C-cadherin to these maps is consistent with a flexible intermolecular interface mediated by an exchange of amino-terminal tryptophans. This flexibility suggests a novel mechanism for generating both cis and trans interactions and for propagating these adhesive interactions along the junction.
リンク	Science / PubMed:14526082
手法	EM (トモグラフィー)
解像度	20.0 - 30.0 Å
構造データ	1051 1q55 1q5a 1q5b 1q5c EMDB-1051: Untangling desmosomal knots with electron tomography. PDB-1q55: W-shaped trans interactions of cadherins model based on fitting C-cadherin (1L3W) to 3D map of desmosomes obtained by electron tomography PDB-1q5a: S-shaped trans interactions of cadherins model based on fitting C-cadherin (1L3W) to 3D map of desmosomes obtained by electron tomography PDB-1q5b: lambda-shaped TRANS and CIS interactions of cadherins model based on fitting C-cadherin (1L3W) to 3D map of desmosomes obtained by electron tomography PDB-1q5c: S-S-lambda-shaped TRANS and CIS interactions of cadherins model based on fitting C-cadherin (1L3W) to 3D map of desmosomes obtained by electron tomography 手法: EM (トモグラフィー) / 解像度: 30.0 Å 1052 1q55 1q5a 1q5b 1q5c EMDB-1052: Untangling desmosomal knots with electron tomography. PDB-1q55: W-shaped trans interactions of cadherins model based on fitting C-cadherin (1L3W) to 3D map of desmosomes obtained by electron tomography PDB-1q5a: S-shaped trans interactions of cadherins model based on fitting C-cadherin (1L3W) to 3D map of desmosomes obtained by electron tomography PDB-1q5b: lambda-shaped TRANS and CIS interactions of cadherins model based on fitting C-cadherin (1L3W) to 3D map of desmosomes obtained by electron tomography PDB-1q5c: S-S-lambda-shaped TRANS and CIS interactions of cadherins model based on fitting C-cadherin (1L3W) to 3D map of desmosomes obtained by electron tomography 手法: EM (トモグラフィー) / 解像度: 30.0 Å 1053 1q5b EMDB-1053: Untangling desmosomal knots with electron tomography. PDB-1q5b: lambda-shaped TRANS and CIS interactions of cadherins model based on fitting C-cadherin (1L3W) to 3D map of desmosomes obtained by electron tomography 手法: EM (トモグラフィー) / 解像度: 20.0 Å
化合物	ChemComp-NAG: 2-acetamido-2-deoxy-beta-D-glucopyranose / N-アセチル-β-D-グルコサミン ChemComp-NDG: 2-acetamido-2-deoxy-alpha-D-glucopyranose / N-アセチル-α-D-グルコサミン ChemComp-CA: Unknown entry / カルシウムジカチオン
由来	mus musculus (ハツカネズミ)
キーワード	STRUCTURAL PROTEIN / CADHERIN; TRANS INTERACTION; DESMOSOME; JUNCTION; ADHESION