EMDB/PDB/SASBDBから引用されている文献のデータベース

キーワード
構造解析手法	All X線回折 NMR 電子顕微鏡小角散乱中性子線回折線維回折粉末回折赤外分光 EPR FRET 理論モデルハイブリッド
著者・登録者
ジャーナル
IF	>30 >20 >10 >5 all

タイトル	Studies on the Nitroreductase Prodrug-Activating System. Crystal Structures of Complexes with the Inhibitor Dicoumarol and Dinitrobenzamide Prodrugs and of the Enzyme Active Form.
ジャーナル・号・ページ	J. Med. Chem., Vol. 46, Page 4009-4020, Year 2003
掲載日	2001年4月5日 (構造データの登録日)
著者	Johansson, E. / Parkinson, G.N. / Denny, W.A. / Neidle, S.
リンク	J. Med. Chem. / PubMed:12954054
手法	X線回折
解像度	2 - 2.5 Å
構造データ	PDB-1idt: STRUCTURAL STUDIES ON A PRODRUG-ACTIVATING SYSTEM-CB1954 AND FMN-DEPENDENT NITROREDUCTASE 手法: X-RAY DIFFRACTION / 解像度: 2 Å PDB-1oo5: Studies on the Nitroreductase Prodrug-Activating System. Crystal Structures of the Enzyme Active Form and Complexes with the Inhibitor Dicoumarol and Dinitrobenzamide Prodrugs 手法: X-RAY DIFFRACTION / 解像度: 2.5 Å PDB-1oo6: Nitroreductase from e-coli in complex with the dinitrobenzamide prodrug SN23862 手法: X-RAY DIFFRACTION / 解像度: 2 Å PDB-1oon: Nitroreductase from e-coli in complex with the dinitrobenzamide prodrug SN27217 手法: X-RAY DIFFRACTION / 解像度: 2.49 Å PDB-1ooq: Nitroreductase from e-coli in complex with the inhibitor dicoumarol 手法: X-RAY DIFFRACTION / 解像度: 2 Å
化合物	ChemComp-FMN: FLAVIN MONONUCLEOTIDE / FMN ChemComp-CB1: 5-(AZIRIDIN-1-YL)-2,4-DINITROBENZAMIDE ChemComp-HOH: WATER ChemComp-SN2: 5-[BIS-2(CHLORO-ETHYL)-AMINO]-2,4-DINTRO-BENZAMIDE ChemComp-BEL: 2,4-DINITRO,5-[BIS(2-BROMOETHYL)AMINO]-N-(2',3'-DIOXOPROPYL)BENZAMIDE ChemComp-DTC: BISHYDROXY[2H-1-BENZOPYRAN-2-ONE,1,2-BENZOPYRONE] / 抗凝固剤, 阻害剤*YM
由来	escherichia coli (大腸菌)
キーワード	OXIDOREDUCTASE / FMN / bioreductive activation / prodrug / NAD(P)H-QUINONE REDUCTASE / NITROREDUCTASE / FLAVOPROTEIN / SN23862 / SN27217 / DICOUMAROL