タイトル | Structures of human thymidylate kinase in complex with prodrugs: implications for the structure-based design of novel compounds |
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ジャーナル・号・ページ | Biochemistry, Vol. 42, Page 2568-2577, Year 2003 |
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掲載日 | 2003年1月12日 (構造データの登録日) |
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著者 | Ostermann, N. / Segura-Pena, D. / Meier, C. / Veit, T. / Monnerjahn, M. / Konrad, M. / Lavie, A. |
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リンク | Biochemistry / PubMed:12614151 |
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手法 | X線回折 |
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解像度 | 1.5 - 1.9 Å |
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構造データ | PDB-1nmx: Crystal structure of human thymidylate kinase with FLTMP and ADP 手法: X-RAY DIFFRACTION / 解像度: 1.7 Å PDB-1nmy: Crystal structure of human thymidylate kinase with FLTMP and AppNHp 手法: X-RAY DIFFRACTION / 解像度: 1.6 Å PDB-1nmz: Crystal structure of human thymidylate kinase with NH2TMP and AppNHp 手法: X-RAY DIFFRACTION / 解像度: 1.75 Å PDB-1nn0: Crystal structure of human thymidylate kinase with ddTMP and ADP 手法: X-RAY DIFFRACTION / 解像度: 1.6 Å PDB-1nn1: Crystal structure of human thymidylate kinase with ddTMP and AppNHp 手法: X-RAY DIFFRACTION / 解像度: 1.9 Å PDB-1nn3: Crystal structure of human thymidylate kinase with d4TMP + ADP 手法: X-RAY DIFFRACTION / 解像度: 1.55 Å PDB-1nn5: Crystal structure of human thymidylate kinase with d4TMP + AppNHp 手法: X-RAY DIFFRACTION / 解像度: 1.5 Å |
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化合物 | ChemComp-ANP: PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER / AMP-PNP / AMP-PNP, エネルギー貯蔵分子類似体*YM
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由来 | homo sapiens (ヒト)
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キーワード | TRANSFERASE / thymidylate kinase / p-loop / fluorothymidine / aminothymidine / dideoxythymidine / d4TMP |
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