Multi-targeted antifolates aimed at avoiding drug resistance form covalent closed inhibitory complexes with human and Escherichia coli thymidylate synthases.
PDB-1jtq: E. coli TS Complex with dUMP and the Pyrrolo(2,3-d)pyrimidine-based Antifolate LY341770 手法: X-RAY DIFFRACTION / 解像度: 2.5 Å
PDB-1jtu: E. coli Thymidylate Synthase in a Complex with dUMP and LY338913, A Polyglutamylated Pyrrolo(2,3-d)pyrimidine-based Antifolate 手法: X-RAY DIFFRACTION / 解像度: 2.2 Å
PDB-1ju6: Human Thymidylate Synthase Complex with dUMP and LY231514, A Pyrrolo(2,3-d)pyrimidine-based Antifolate 手法: X-RAY DIFFRACTION / 解像度: 2.89 Å
PDB-1juj: Human Thymidylate Synthase Bound to dUMP and LY231514, a Pyrrolo(2,3-d)pyrimidine-based Antifolate 手法: X-RAY DIFFRACTION / 解像度: 3 Å
PDB-1jut: E. coli Thymidylate Synthase Bound to dUMP and LY338529, A Pyrrolo(2,3-d)pyrimidine-based Antifolate 手法: X-RAY DIFFRACTION / 解像度: 2.7 Å