タイトル | Crystal structures of human factor Xa complexed with potent inhibitors. |
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ジャーナル・号・ページ | J. Med. Chem., Vol. 43, Page 3226-3232, Year 2000 |
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掲載日 | 2000年5月11日 (構造データの登録日) |
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著者 | Maignan, S. / Guilloteau, J.P. / Pouzieux, S. / Choi-Sledeski, Y.M. / Becker, M.R. / Klein, S.I. / Ewing, W.R. / Pauls, H.W. / Spada, A.P. / Mikol, V. |
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リンク | J. Med. Chem. / PubMed:10966741 |
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手法 | X線回折 |
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解像度 | 1.8 - 2.2 Å |
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構造データ | PDB-1ezq: CRYSTAL STRUCTURE OF HUMAN COAGULATION FACTOR XA COMPLEXED WITH RPR128515 手法: X-RAY DIFFRACTION / 解像度: 2.2 Å PDB-1f0r: CRYSTAL STRUCTURE OF HUMAN COAGULATION FACTOR XA COMPLEXED WITH RPR208815 手法: X-RAY DIFFRACTION / 解像度: 2.1 Å PDB-1f0s: Crystal Structure of Human Coagulation Factor XA Complexed with RPR208707 手法: X-RAY DIFFRACTION / 解像度: 2.1 Å PDB-1f0t: BOVINE TRYPSIN COMPLEXED WITH RPR131247 手法: X-RAY DIFFRACTION / 解像度: 1.8 Å PDB-1f0u: BOVINE TRYPSIN COMPLEXED WITH RPR128515 手法: X-RAY DIFFRACTION / 解像度: 1.9 Å |
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化合物 | ChemComp-RPR: 3-[(3'-AMINOMETHYL-BIPHENYL-4-CARBONYL)-AMINO]-2-(3-CARBAMIMIDOYL-BENZYL)-BUTYRIC ACID METHYL ESTER / RPR-128515
ChemComp-815: THIENO[3,2-B]PYRIDINE-2-SULFONIC ACID [1-(1-AMINO-ISOQUINOLIN-7-YLMETHYL)-2-OXO-PYRROLDIN-3-YL]-AMIDE / RPR-208815
ChemComp-PR1: 4-HYDROXY-3-[2-OXO-3-(THIENO[3,2-B]PYRIDINE-2-SULFONYLAMINO)-PYRROLIDIN-1-YLMETHYL]-BENZAMIDINE / RPR-131247
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由来 | homo sapiens (ヒト)![](img/tx_mammal.gif) bos taurus (ウシ)
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キーワード | HYDROLASE / Protein-inhibitor complex |
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