タイトル | Optimization of P1-P3 groups in symmetric and asymmetric HIV-1 protease inhibitors. |
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ジャーナル・号・ページ | Eur. J. Biochem., Vol. 270, Page 1746-1758, Year 2003 |
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掲載日 | 1999年10月4日 (構造データの登録日) |
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著者 | Andersson, H.O. / Fridborg, K. / Lowgren, S. / Alterman, M. / Muhlman, A. / Bjorsne, M. / Garg, N. / Kvarnstrom, I. / Schaal, W. / Classon, B. ...Andersson, H.O. / Fridborg, K. / Lowgren, S. / Alterman, M. / Muhlman, A. / Bjorsne, M. / Garg, N. / Kvarnstrom, I. / Schaal, W. / Classon, B. / Karlen, A. / Danielsson, U.H. / Ahlsen, G. / Nillroth, U. / Vrang, L. / Oberg, B. / Samuelsson, B. / Hallberg, A. / Unge, T. |
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リンク | Eur. J. Biochem. / PubMed:12694187 |
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手法 | X線回折 |
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解像度 | 1.8 - 2.294 Å |
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構造データ | PDB-1d4h: HIV-1 Protease in complex with the inhibitor BEA435 手法: X-RAY DIFFRACTION / 解像度: 1.81 Å PDB-1d4i: HIV-1 protease in complex with the inhibitor BEA425 手法: X-RAY DIFFRACTION / 解像度: 1.81 Å PDB-1d4j: HIV-1 protease in complex with the inhibitor MSL370 手法: X-RAY DIFFRACTION / 解像度: 1.81 Å PDB-1ebw: HIV-1 protease in complex with the inhibitor BEA322 手法: X-RAY DIFFRACTION / 解像度: 1.81 Å PDB-1eby: HIV-1 protease in complex with the inhibitor BEA369 手法: X-RAY DIFFRACTION / 解像度: 2.294 Å PDB-1ebz: HIV-1 protease in complex with the inhibitor BEA388 手法: X-RAY DIFFRACTION / 解像度: 2.01 Å PDB-1ec1: HIV-1 protease in complex with the inhibitor BEA409 手法: X-RAY DIFFRACTION / 解像度: 2.1 Å PDB-1ec2: HIV-1 protease in complex with the inhibitor BEA428 手法: X-RAY DIFFRACTION / 解像度: 2 Å PDB-1ec3: HIV-1 protease in complex with the inhibitor MSA367 手法: X-RAY DIFFRACTION / 解像度: 1.8 Å |
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化合物 | ChemComp-BEH: 2,5-DIBENZYLOXY-3,4-DIHYDROXY-HEXANEDIOIC ACID BENZYLAMIDE (2-HYDROXY-INDAN-1-YL)-AMIDE
ChemComp-MSC: 2,5-DIBENZYLOXY-3,4-DIHYDROXY-HEXANEDIOIC ACID 2-CHLORO-6-FLUORO-BENZYLAMIDE (2-HYDROXY-INDAN-1- YL)-AMIDE
ChemComp-BEC: [5-(2-HYDROXY-INDAN-1-YLCARBAMOYL)-3,4-DIHYDROXY-2,5-[DIBENZYL-OXY]-PENTANOYL]-VALINYL-AMIDO-METHANE
ChemComp-MS3: N,N-[2,5-O-DIBENZYL-GLUCARYL]-DI-[VALINYL-AMINOMETHANYL-PYRIDINE]
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由来 | ![](img/tx_virus.gif) human immunodeficiency virus (ヒト免疫不全ウイルス)![](img/tx_virus.gif) human immunodeficiency virus 1 (ヒト免疫不全ウイルス)
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キーワード | HYDROLASE / DIMER / HYDROLASE/HYDROLASE INHIBITOR / protein-inhibitor complex / HYDROLASE-HYDROLASE INHIBITOR COMPLEX |
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