タイトル | Structural Determinations of Phosphoinositide 3-Kinase Inhibition by Wortmannin, Ly294002, Quercetin, Myricetin and Staurosporine |
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ジャーナル・号・ページ | Mol. Cell, Vol. 6, Page 909-, Year 2000 |
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掲載日 | 2000年9月8日 (構造データの登録日) |
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著者 | Walker, E.H. / Pacold, M.E. / Perisic, O. / Stephens, L. / Hawkins, P.T. / Whymann, M.P. / Williams, R.L. |
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リンク | Mol. Cell / PubMed:11090628 |
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手法 | X線回折 |
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解像度 | 2 - 2.7 Å |
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構造データ | PDB-1e7u: Structure determinants of phosphoinositide 3-kinase inhibition by wortmannin, LY294002, quercetin, myricetin and staurosporine 手法: X-RAY DIFFRACTION / 解像度: 2 Å PDB-1e7v: Structure determinants of phosphoinositide 3-kinase inhibition by wortmannin, LY294002, quercetin, myricetin and staurosporine 手法: X-RAY DIFFRACTION / 解像度: 2.4 Å PDB-1e8w: Structure determinants of phosphoinositide 3-kinase inhibition by wortmannin, LY294002, quercetin, myricetin and staurosporine 手法: X-RAY DIFFRACTION / 解像度: 2.5 Å PDB-1e8x: STRUCTURAL INSIGHTS INTO PHOSHOINOSITIDE 3-KINASE ENZYMATIC MECHANISM AND SIGNALLING 手法: X-RAY DIFFRACTION / 解像度: 2.2 Å PDB-1e8y: Structure determinants of phosphoinositide 3-kinase inhibition by wortmannin, LY294002, quercetin, myricetin and staurosporine 手法: X-RAY DIFFRACTION / 解像度: 2 Å PDB-1e8z: Structure determinants of phosphoinositide 3-kinase inhibition by wortmannin, LY294002, quercetin, myricetin and staurosporine 手法: X-RAY DIFFRACTION / 解像度: 2.4 Å PDB-1e90: Structure determinants of phosphoinositide 3-kinase inhibition by wortmannin, LY294002, quercetin, myricetin and staurosporine 手法: X-RAY DIFFRACTION / 解像度: 2.7 Å |
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化合物 | ChemComp-KWT: (1S,6BR,9AS,11R,11BR)-9A,11B-DIMETHYL-1-[(METHYLOXY)METHYL]-3,6,9-TRIOXO-1,6,6B,7,8,9,9A,10,11,11B-DECAHYDRO-3H-FURO[4, / ウォルトマンニン / 阻害剤*YM
ChemComp-MYC: 3,5,7-TRIHYDROXY-2-(3,4,5-TRIHYDROXYPHENYL)-4H-CHROMEN-4-ONE / ミリセチン
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由来 | - sus scrofa (ブタ)
- homo sapiens (ヒト)
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キーワード | PHOSPHOINOSITIDE 3-KINASE GAMMA / SECONDARY MESSENGER GENERATION / PI3K / PI 3K / WORTMANNIN / TRANSFERASE / SECONDARY MESSENGER GENERATION PI3K / LY294002 / QUERCETIN / STAUROSPORINE / MYRICETIN |
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