タイトル Structures of three inhibitor complexes provide insight into the reaction mechanism of the human methylenetetrahydrofolate dehydrogenase/cyclohydrolase. ジャーナル・号・ページ Biochemistry , Vol. 39, Page 6325-6335, Year 2000掲載日 1999年11月29日 (構造データの登録日) 著者Schmidt, A. / Wu, H. / MacKenzie, R.E. / Chen, V.J. / Bewly, J.R. / Ray, J.E. / Toth, J.E. / Cygler, M. リンク Biochemistry / PubMed:10828945手法 X線回折 解像度 2.2 - 2.7 Å 構造データ PDB-1dia : 構造ビューア HUMAN METHYLENETETRAHYDROFOLATE DEHYDROGENASE / CYCLOHYDROLASE COMPLEXED WITH NADP AND INHIBITOR LY249543 手法 : X-RAY DIFFRACTION / 解像度 : 2.2 Å
PDB-1dib : 構造ビューア HUMAN METHYLENETETRAHYDROFOLATE DEHYDROGENASE / CYCLOHYDROLASE COMPLEXED WITH NADP AND INHIBITOR LY345899 手法 : X-RAY DIFFRACTION / 解像度 : 2.7 Å
PDB-1dig : 構造ビューア HUMAN METHYLENETETRAHYDROFOLATE DEHYDROGENASE / CYCLOHYDROLASE COMPLEXED WITH NADP AND INHIBITOR LY374571 手法 : X-RAY DIFFRACTION / 解像度 : 2.2 Å
化合物 ChemComp-NAP : 構造ビューア NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE
ChemComp-L24 : 構造ビューア [[[2-AMINO-5,6,7,8-TETRAHYDRO-4-HYDROXY-PYRIDO[2,3-D]PYRIMIDIN-6-YL]-ETHYL]-PHENYL]-CARBONYL-GLUTAMIC ACID / Ly-249543
ChemComp-L34 : 構造ビューア 4-(7-AMINO-9-HYDROXY-1-OXO-3,3A,4,5-TETRAHYDRO-2,5,6,8,9B-PENTAAZA-CYCLOPENTA[A]NAPHTHALEN-2-YL)-PHENYLCARBONYL-GLUTAMI
ChemComp-L37 : 構造ビューア [[N'-(2,5-DIAMINO-6-HYDROXY-PYRIMIDIN-4-YL)-UREAYL]-PHEN-4-YL]-CARBONYL-GLUTAMIC ACID
由来 homo sapiens (ヒト) キーワード OXIDOREDUCTASE / HYDROLASE / TETRAHYDROFOLATE / DEHYDROGENASE / CYCLOHYDROLASE / NADP / INHIBITOR / ROSSMANN FOLD