タイトル | Molecular recognition of macrocyclic peptidomimetic inhibitors by HIV-1 protease. |
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ジャーナル・号・ページ | Biochemistry, Vol. 38, Page 7978-7988, Year 1999 |
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掲載日 | 1999年1月17日 (構造データの登録日) |
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著者 | Martin, J.L. / Begun, J. / Schindeler, A. / Wickramasinghe, W.A. / Alewood, D. / Alewood, P.F. / Bergman, D.A. / Brinkworth, R.I. / Abbenante, G. / March, D.R. ...Martin, J.L. / Begun, J. / Schindeler, A. / Wickramasinghe, W.A. / Alewood, D. / Alewood, P.F. / Bergman, D.A. / Brinkworth, R.I. / Abbenante, G. / March, D.R. / Reid, R.C. / Fairlie, D.P. |
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リンク | Biochemistry / PubMed:10387041 |
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手法 | X線回折 |
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解像度 | 1.75 - 2 Å |
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構造データ | PDB-1b6j: HIV-1 PROTEASE COMPLEXED WITH MACROCYCLIC PEPTIDOMIMETIC INHIBITOR 1 手法: X-RAY DIFFRACTION / 解像度: 1.85 Å PDB-1b6k: HIV-1 PROTEASE COMPLEXED WITH MACROCYCLIC PEPTIDOMIMETIC INHIBITOR 5 手法: X-RAY DIFFRACTION / 解像度: 1.85 Å PDB-1b6l: HIV-1 PROTEASE COMPLEXED WITH MACROCYCLIC PEPTIDOMIMETIC INHIBITOR 4 手法: X-RAY DIFFRACTION / 解像度: 1.75 Å PDB-1b6m: HIV-1 PROTEASE COMPLEXED WITH MACROCYCLIC PEPTIDOMIMETIC INHIBITOR 6 手法: X-RAY DIFFRACTION / 解像度: 1.85 Å PDB-1b6p: HIV-1 PROTEASE COMPLEXED WITH MACROCYCLIC PEPTIDOMIMETIC INHIBITOR 7 手法: X-RAY DIFFRACTION / 解像度: 2 Å PDB-1z1h: HIV-1 protease complexed with macrocyclic peptidomimetic inhibitor 3 手法: X-RAY DIFFRACTION / 解像度: 1.85 Å PDB-1z1r: HIV-1 protease complexed with Macrocyclic peptidomimetic inhibitor 2 手法: X-RAY DIFFRACTION / 解像度: 1.85 Å |
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化合物 | ChemComp-PI5: N-[3-(8-SEC-BUTYL-7,10-DIOXO-2-OXA-6,9-DIAZA-BICYCLO[11.2.2]HEPTADECA-1(16),13(17),14- TRIEN-11-YLAMINO)-2-HYDROXY-1-(4-HYDROXY-BENZYL)-PROPYL]-3-METHYL-2- (2-OXO-PYRROLIDIN-1-YL)-BUTYRAMIDE
ChemComp-PI6: [1-BENZYL-3-(8-SEC-BUTYL-7,10-DIOXO-2-OXA-6,9-DIAZA-BICYCLO[11.2.2] HEPTADECA-1(16),13(17),14-TRIEN-11-YLAMINO)-2-HYDROXY-PROPYL]-CARBAMIC ACID TERT-BUTYL ESTER
ChemComp-PI7: N-[3-(8-SEC-BUTYL-7,10-DIOXO-2-OXA-6,9-DIAZA-BICYCLO[11.2.2]
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由来 | - human immunodeficiency virus 1 (ヒト免疫不全ウイルス)
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キーワード | HYDROLASE/HYDROLASE INHIBITOR / COMPLEX (ACID PROTEINASE-PEPTIDE) / HYDROLASE-HYDROLASE INHIBITOR COMPLEX / HYDROLASE / macrocyclic inhibitors / peptidomimetic inhibitors / HIV1 protease |
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