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-Structure paper
タイトル | Coagulation factor X activates innate immunity to human species C adenovirus. |
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ジャーナル・号・ページ | Science, Vol. 338, Issue 6108, Page 795-798, Year 2012 |
掲載日 | 2012年11月9日 |
著者 | Konstantin Doronin / Justin W Flatt / Nelson C Di Paolo / Reeti Khare / Oleksandr Kalyuzhniy / Mauro Acchione / John P Sumida / Umeharu Ohto / Toshiyuki Shimizu / Sachiko Akashi-Takamura / Kensuke Miyake / James W MacDonald / Theo K Bammler / Richard P Beyer / Frederico M Farin / Phoebe L Stewart / Dmitry M Shayakhmetov / |
PubMed 要旨 | Although coagulation factors play a role in host defense for "living fossils" such as horseshoe crabs, the role of the coagulation system in immunity in higher organisms remains unclear. We modeled ...Although coagulation factors play a role in host defense for "living fossils" such as horseshoe crabs, the role of the coagulation system in immunity in higher organisms remains unclear. We modeled the interface of human species C adenovirus (HAdv) interaction with coagulation factor X (FX) and introduced a mutation that abrogated formation of the HAdv-FX complex. In vivo genome-wide transcriptional profiling revealed that FX-binding-ablated virus failed to activate a distinct network of nuclear factor κB-dependent early-response genes that are activated by HAdv-FX complex downstream of TLR4/MyD88/TRIF/TRAF6 signaling. Our study implicates host factor "decoration" of the virus as a mechanism to trigger an innate immune sensor that responds to a misplacement of coagulation FX from the blood into intracellular macrophage compartments upon virus entry into the cell. |
リンク | Science / PubMed:23019612 / PubMed Central |
手法 | EM (単粒子) |
解像度 | 11.1 Å |
構造データ | EMDB-5494: |