タイトル Cat1 forms filament networks to degrade NAD during the type III CRISPR-Cas antiviral response ジャーナル・号・ページ Science , Year 2025掲載日 2025年1月13日 (構造データの登録日) 著者Baca CF / Majumder P / Hickling JH / Patel DJ / Marraffini LA リンク Science / PubMedで検索 手法 EM (単粒子) 解像度 3.0 - 4.0 Å 構造データ EMDB-48629 , PDB-9mud : Cryo-EM structure of CRISPR-associated cA4 bound Cat1 Pentagonal filament assembly 手法 : EM (単粒子) / 解像度 : 3.4 Å
EMDB-48630 , PDB-9mue : Cryo-EM structure of CRISPR-associated cA4 bound Cat1 Pentagonal filament assembly in the presence of NAD (ADPR modelled) 手法 : EM (単粒子) / 解像度 : 4.0 Å
EMDB-48639 , PDB-9muo : Cryo-EM structure of CRISPR-associated cA4 bound Cat1 Pentagonal filament assembly in the presence of NAD analog BAD 手法 : EM (単粒子) / 解像度 : 3.3 Å
EMDB-48698 , PDB-9mw9 : Cryo-EM structure of CRISPR-associated cA4 bound Cat1 Trigonal filament assembly手法 : EM (単粒子) / 解像度 : 3.0 Å
化合物 ChemComp-AR6 : 構造ビューア [(2R,3S,4R,5R)-5-(6-AMINOPURIN-9-YL)-3,4-DIHYDROXY-OXOLAN-2-YL]METHYL
ChemComp-DQV : 構造ビューア [(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl]methyl [(2R,3S,4R,5S)-5-(3-carbamoylphenyl)-3,4-dihydroxytetrahydrofuran-2-yl]methyl dihydrogen diphosphate (non-preferred name) / BAD
由来 bacterium (バクテリア)synthetic construct (人工物) キーワード ANTIVIRAL PROTEIN / CRISPR / antiphage defense / adaptive immunity / Filament / CARF / TIR / cA4 / NAD / ADPR / NAM / BAD